Role of 5-HT3 and 5-HT2C receptors located within the medial amygdala in the control of salt intake in sodium-depleted rats.

Full Abstract

In the present study, we investigated the role of 5-HT(3) and 5-HT(2C) receptors located within the medial amygdala (MeA) in the control of water and salt intake in sodium-depleted rats. Pharmacological activation of 5-HT(3) receptors located in the medial amygdala by the selective 5-HT(3) receptor agonist m-CPBG significantly reduced salt intake in sodium-depleted rats, an effect that is reverted by pretreatment with the selective 5-HT(3) receptor antagonist ondansetron. In addition, the injection of ondansetron alone into the medial amygdala had no effect on salt intake in sodium-depleted and in sodium-repleted rats. Pharmacological stimulation of 5-HT(2C) receptors located in the medial amygdala by the selective 5-HT(2C) receptor agonist m-CPP failed to modify salt intake in sodium-depleted rats, whereas the blockade of these receptors by the selective 5-HT(2C) receptor antagonist SDZ SER 082 significantly reduced salt intake in this same group of animals. These results lead to the conclusion that the pharmacological activation of 5-HT(3) receptors located within the MeA inhibits salt intake in sodium-depleted rats and that, in this same brain region, the functional integrity of 5-HT(2C) receptors is required to achieve the full expression of sodium appetite in sodium-depleted rats.

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Author information

Author/s: Luz, Carla (C); Souza, Anderson (A); Reis, Rodolfo (R); Fregoneze, Josmara Bartolomei (JB); de Castro e Silva, Emilio (E);

Affiliation: Department of Biological Sciences, State University of Southwest Bahia, Jequié, Brazil.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Brain research (Brain Res), published in Netherlands. (Language: eng)

Reference: 2006-Jul; vol 1099 (issue 1) : pp 121-32

Dates: Created 2006/07/25; Completed 2006/09/19; Revised 2006/11/15;

PMID: 16765332, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amygdala - drug effects; metabolism
Analysis of Variance
Animals
Avoidance Learning - drug effects; physiology
Behavior, Animal
Biguanides - pharmacology
Dose-Response Relationship, Drug
Drinking - drug effects
Drug Interactions
Feeding Behavior - drug effects; physiology
Furosemide - toxicity
Male

Male
Ondansetron - pharmacology
Rats
Rats, Wistar
Receptor, Serotonin, 5-HT2C - physiology
Receptors, Serotonin, 5-HT3 - physiology
Renal Insufficiency - chemically induced; metabolism; physiopathology
Saccharin - metabolism
Serotonin Agonists - pharmacology
Serotonin Antagonists - pharmacology
Sodium - deficiency; metabolism
Time Factors

Associated Chemicals: Biguanides (0) ; Receptor, Serotonin, 5-HT2C (0) ; Receptors, Serotonin, 5-HT3 (0) ; Serotonin Agonists (0) ; Serotonin Antagonists (0) ; 1-(3-chlorophenyl)biguanide (48144-44-1) ; Furosemide (54-31-9) ; Sodium (7440-23-5) ; Saccharin (81-07-2) ; Ondansetron (99614-02-5)

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