Lobeline augments and inhibits cocaine-induced hyperactivity in rats.

Full Abstract

Lobeline has high affinity for nicotinic receptors and alters presynaptic dopamine storage and release in brain. Moreover, lobeline decreases the reinforcing and locomotor-activating properties of methamphetamine, suggesting that lobeline may be a pharmacotherapy for psychostimulant abuse. This study determined if lobeline alters cocaine-induced hyperactivity and if lobeline alters the induction and/or expression of sensitization to cocaine. On Days 1-12, male rats were administered lobeline (0.3 or 1.0 mg/kg) or saline, placed in an automated activity monitor for 20 min, administered cocaine (10, 20 or 30 mg/kg) or saline and returned to the monitor for 60 min. On Day 13, the effect of lobeline on the induction and expression of sensitization to cocaine was determined. Lobeline did not alter the effect of cocaine after acute injection. However, 1.0 mg/kg lobeline attenuated cocaine (10 and 20 mg/kg)-induced hyperactivity after repeated administration and prevented the development of sensitization to these cocaine doses. Interestingly, 0.3 mg/kg lobeline augmented cocaine (10 mg/kg)-induced hyperactivity after repeated administration. Lobeline did not alter the effect of 30 mg/kg cocaine. The present results indicate a complex interaction of lobeline with cocaine and support other research indicating a role for nicotinic receptors in the development of sensitization to psychostimulants.

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Author information

Author/s: Polston, James E (JE); Cunningham, Colin S (CS); Rodvelt, Kelli R (KR); Miller, Dennis K (DK);

Affiliation: Department of Psychological Sciences and Interdisciplinary Neuroscience Program, University of Missouri, Columbia, MO 65211, USA.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Life sciences (Life Sci), published in England. (Language: eng)

Reference: 2006-Aug; vol 79 (issue 10) : pp 981-90

Dates: Created 2006/07/21; Completed 2006/08/29; Revised 2006/11/15;

PMID: 16765386, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Cocaine - pharmacology
Cocaine-Related Disorders - complications; drug therapy
Drug Administration Schedule
Drug Interactions
Lobeline - administration & dosage; pharmacology

Male
Motor Activity - drug effects
Psychomotor Agitation - drug therapy; etiology
Rats
Rats, Sprague-Dawley
Receptors, Nicotinic - drug effects; physiology

Associated Chemicals: Receptors, Nicotinic (0) ; Cocaine (50-36-2) ; Lobeline (90-69-7)

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