Comparison of the effects of a 24-hour nicotine patch and a 16-hour nicotine patch on smoking urges and sleep.

Full Abstract

This randomized, open-label, crossover study was conducted to compare the effects of a 24-hr nicotine patch and a 16-hr nicotine patch on morning smoking urges and sleep quality of dependent smokers during a short period of cigarette abstinence. A total of 20 smokers (9 women and 11 men) smoking at least 20 cigarettes/day completed the two smoke-free study periods. For each period, cigarette abstinence started on the first evening and a nicotine patch was applied the next morning (for 16 or 24 hr), after baseline measures; a second patch was applied the next morning, 1 hr before the end of the experimental period. Smoking urges, mood and behavior self-reports, psychomotor performance, and polysomnographic recordings were compared between the two types of nicotine patch according to changes from baseline. Both patches decreased morning smoking urges, although results were significantly superior for the 24-hr patch. Furthermore, the 24-hr patch was more effective than the 16-hr patch in reducing the positive reinforcing dimension of smoking urges. Regarding polysomnographic recordings, the proportion of slow wave sleep was significantly increased from baseline with the 24-hr patch compared with the 16-hr patch. As for psychomotor performance measured through the critical flicker fusion test, significant improvement in morning alertness was observed in the 24-hr patch group. In conclusion, the 24-hr nicotine patch formulation is more effective than the 16-hr formulation in alleviating morning smoking urges and more specifically the positive reinforcing factor. The present findings do not support the idea that nicotine delivery during bedtime might disturb sleep, but rather it improves restorative sleep and postwaking arousal.

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Author information

Author/s: Aubin, Henri-Jean (HJ); Luthringer, Rémy (R); Demazières, Agnès (A); Dupont, Christine (C); Lagrue, Gilbert (G);

Affiliation: Centre de Traitement des Addictions, Hôpital Emile Roux, Limeil Brevannes, France.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (Nicotine Tob Res), published in England. (Language: eng)

Reference: 2006-Apr; vol 8 (issue 2) : pp 193-201

Dates: Created 2006/06/12; Completed 2006/09/14; Revised 2006/11/15;

PMID: 16766412, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Administration, Cutaneous
Adult
Cross-Over Studies
Dose-Response Relationship, Drug
Female
Humans
Male
Middle Aged
Nicotine - administration & dosage

Nicotine - administration & dosage
Nicotinic Agonists - administration & dosage
Polysomnography
Sleep - drug effects
Smoking Cessation - methods
Statistics, Nonparametric
Substance Withdrawal Syndrome - drug therapy; prevention & control
Tobacco Use Disorder - drug therapy
Treatment Outcome

Associated Chemicals: Nicotinic Agonists (0) ; Nicotine (54-11-5)

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