[Experimental models of insulin resistance and obesity: lessons learned]

(Modelos experimentais de resistência à insulina e obesidade: lições aprendidas.)

Full Abstract

For better understanding the role of each element involved in the physiopathology of obesity and insulin resistance, researchers can use experimental models, which may in controlled manner evaluate the participation of each element on the obesity and insulin resistance and provide information for better understanding the physiopathology and treatment of obesity and insulin resistance. Experimental obesity and insulin resistance can be due to a deficient response to leptin, secondary to hypoleptinemia and/or mutations on leptin receptor, by modifications on insulin receptor, deletion or diminished insulin signal transduction, enhancement of the effects of orexigen peptides and/or diminution of anorexigen peptides actions on hypothalamus, as well as secondary to arterial hypertension, as in the spontaneously hypertension. Obesity and insulin resistance can also be induced by glucocorticoid excess, frutose enriched and cafeteria diet and due to hypothalamus lesions induced by neonatal administration of monossodium glutamate.

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Author information

Author/s: Cesaretti, Mario Luís Ribeiro (ML); Kohlmann Junior, Osvaldo (O);

Affiliation: Laboratório de Hipertensão Arterial, Universidade Federal de São Paulo, São Paulo, SP. cesaretti(-atsign-)nefro.epm.br

Journal and publication information

Publication Type: English Abstract; Journal Article; Review

Journal: Arquivos brasileiros de endocrinologia e metabologia (Arq Bras Endocrinol Metabol), published in Brazil. (Language: por)

Reference: 2006-Apr; vol 50 (issue 2) : pp 190-7

Dates: Created 2006/06/12; Completed 2007/03/08;

PMID: 16767285, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adipose Tissue
Animals
Diet
Disease Models, Animal
Hypertension - physiopathology

Insulin Resistance
Leptin - physiology
Models, Genetic
Models, Immunological
Obesity - physiopathology

Associated Chemicals: Leptin (0)

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