Research article summary (published 21 May 2006):

The broad homeostatic role of natriuretic peptides.

Full Abstract

A brief non-inclusive review on natriuretic peptides (NP), their receptors, and their main functional properties is presented. The three main NP, atrial (ANP), brain (BNP) and C-type (CNP) are considered. Guanylyl cyclase receptors modulate all the known systemic effects of NP. Clearance receptors determine the metabolic disposal of NP and in this manner regulate their plasma levels and/or local tissue concentrations. Structure-function properties, and homeostatic properties of NP receptors are presented. ANP, which plays a major role in pressure-volume homeostasis, is discussed in relationship to its effects on renal hemodynamic and excretory functions, inhibition of the renin-angiotensin-aldosterone system, vasorelaxant, and third-spacing action. For BNP special attention is directed to its role as a negative modulator of ventricular remodeling, in view of its anti-hypertrophic, anti-fibrotic and anti-inflammatory effects in the heart. The major effect of CNP in promoting vertebral and longitudinal bone growth is briefly addressed. Finally, emphasis is placed on the recent discovery that ANP affects fat metabolism in humans due to its powerful lipolytic action.

Author information

Author/s: Maack, Thomas (T);

Affiliation: Department of Physiology and Biophysics, Department of Medicine, Weill Medical College, Cornell University, New York, NY, USA. tmaack(-atsign-)me.cornell.edu

Journal and publication information

Publication Type: Journal Article; Review

Journal: Arquivos brasileiros de endocrinologia e metabologia (Arq Bras Endocrinol Metabol), published in Brazil. (Language: eng)

Reference: 2006-Apr; vol 50 (issue 2) : pp 198-207

Dates: Created 2006/06/12; Completed 2007/03/08;

PMID: 16767286, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adipocytes - physiology Atrial Natriuretic Factor - physiology Blood Pressure Homeostasis - physiology Humans

Humans Lipid Metabolism - physiology Natriuretic Peptide, Brain - physiology Natriuretic Peptide, C-Type - physiology Natriuretic Peptides - physiology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Natriuretic Peptides (0) ; Natriuretic Peptide, Brain (114471-18-0) ; Natriuretic Peptide, C-Type (127869-51-6) ; Atrial Natriuretic Factor (85637-73-6)

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