Effects of ethanol on nicotine-induced conditioned place preference in C57BL/6J mice.

Full Abstract

It has been shown that small doses of ethanol (<or= 1.0 g/kg) may antagonize the discriminative stimulus properties of nicotine. The aim of the present study was to evaluate whether ethanol could antagonize nicotine's rewarding effects in the conditioned place preference procedure. For comparison, effects of ethanol on nicotine-induced seizures were assessed. Male C57BL/6J mice were used in all experiments. Lower doses of nicotine (0.3 and 0.6 mg/kg, s.c.) induced significant conditioned place preference, while higher doses (0.9 and 1.2 mg/kg) induced neither conditioned place preference nor conditioned place aversion. In the following experiments, ethanol (0.5 or 1.0 g/kg, i.p.) was administered 5 min before 0.3 mg/kg nicotine. Ethanol did not antagonize nicotine-induced conditioned place preference. Contrary to our hypothesis, a non-significant (p = 0.07) enhancement of nicotine-induced place preference conditioning was observed in mice pre-treated with 1.0 g/kg ethanol. Both doses of ethanol (0.5 and 1.0 g/kg) suppressed seizures elicited by a high dose of nicotine (6.0 mg/kg). Ethanol totally eliminated clonic-tonic component of nicotine-induced seizures. Maximal blood ethanol levels after i.p. administration of 0.5 or 1.0 g/kg ethanol exceeded 60 and 115 mg%, respectively. The present results may indicate that the rewarding and seizure-inducing effects of nicotine are differentially modulated by clinically relevant concentrations of ethanol in mice.

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Author information

Author/s: Korkosz, Agnieszka (A); Zatorski, Pawel (P); Taracha, Ewa (E); Plaznik, Adam (A); Kostowski, Wojciech (W); Bienkowski, Przemyslaw (P);

Affiliation: Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 9 St., PL-02957 Warsaw, Poland.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry), published in England. (Language: eng)

Reference: 2006-Sep; vol 30 (issue 7) : pp 1283-90

Dates: Created 2006/09/26; Completed 2006/10/31; Revised 2006/11/15;

PMID: 16769170, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
Animals
Behavior, Animal - drug effects
Central Nervous System Depressants - blood; pharmacology
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Drug Interactions

Ethanol - blood; pharmacology
Male
Mice
Mice, Inbred C57BL
Nicotine - pharmacology
Nicotinic Agonists - pharmacology
Reward

Associated Chemicals: Central Nervous System Depressants (0) ; Nicotinic Agonists (0) ; Nicotine (54-11-5) ; Ethanol (64-17-5)

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