Quantification of within- and between-pen transmission of Foot-and-Mouth disease virus in pigs.

Full Abstract

Quantified transmission parameters of Foot-and-Mouth Disease Virus (FMDV) are needed for epidemic models used for control and surveillance. In this study, we quantified the within- and between-pen transmission of FMDV in groups of pigs by estimating the daily transmission rate beta, i.e. the number of secondary infections caused by one infectious pig during one day, using an SIR (susceptible-infectious-removed) model. Within-pen transmission was studied in four groups of ten pigs in which 5 infected and 5 susceptible pigs had direct contact; between-pen transmission was studied in one group of ten pigs in which 5 infected and 5 susceptible pigs had indirect contact. Daily results of virus isolation of oropharyngeal fluid were used to quantify the transmission rate beta, using Generalised Linear Modelling (GLM) and a maximum likelihood method. In addition, we estimated the expected time to infection of the first pig within a pen T(w) and in the indirect-contact pen T(b). The between-pen transmission rate beta(b) was estimated to be 0.59 (0.083-4.18) per day, which was significantly lower than the within-pen transmission rate beta(w) of 6.14 (3.75-10.06). T(w) was 1.6 h, and T(b) was 16 h. Our results show that the transmission rate is influenced by contact structure between pigs.

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Author information

Author/s: Eblé, Phaedra (P); de Koeijer, Aline (A); Bouma, Annemarie (A); Stegeman, Arjan (A); Dekker, Aldo (A);

Affiliation: Central Institute for Animal Disease Control (CIDC-Lelystad), PO Box 2004, 8203 AA Lelystad, The Netherlands. phaedra.eble(-atsign-)wur.nl

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Veterinary research (Vet Res), published in France. (Language: eng)

Reference: -2006 Sep-Oct; vol 37 (issue 5) : pp 647-54

Dates: Created 2006/06/16; Completed 2006/10/26; Revised 2008/11/21;

PMID: 16777036, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animal Husbandry - methods
Animals
Communicable Disease Control
Disease Transmission, Infectious - veterinary
Foot-and-Mouth Disease - transmission
Foot-and-Mouth Disease Virus - isolation & purification

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