Effects of exposure of rat dams to 1-bromopropane during pregnancy and lactation on growth and sexual maturation of their offspring.

Full Abstract

1-Bromopropane (1-BP) exhibits neuroreproductive toxicities in adult rats and humans. Here, we determined the effects of exposure of rat dams to 1-BP during pregnancy and lactation on the growth and sexual maturation of their offspring. In Experiment 1, 40 rats were exposed to 0, 100, 400 and 800ppm 1-BP during pregnancy and lactation for 8h/day. Ten rats that were not placed in chambers throughout the experiment served to observe the effect of separation of dams from offspring. In Experiment 2, three groups of 10 pregnant rats each were exposed to fresh air in three chambers and 10 other rats were exposed to 800ppm 1-BP during pregnancy and lactation for 8h/day. After delivery, offspring of the exposed and non-exposed dams were swapped so that they were nursed by the opposite dams. In Experiment 1, the survival rate and body weight of offspring were lower than the non-exposed in 1-BP dose-dependent manner. In Experiment 2, the survival rate and body weight of offspring (Group A) nursed by exposed dams and those (Group B) of exposed dams were significantly lower than non-exposed groups. The body weight of Group A was lower than that of Group B, although the two groups showed a significant equal decrease in the survival rate. The number of dead offspring from Group A was significantly higher. Our results indicate that exposure to 1-BP during pregnancy and lactation has comparable effects on survival rate, but exposure during lactation has a more adverse effect on growth of offspring than that during pregnancy. Moreover, exposure during lactation is associated with reduced early survival of third generation (F2) rats.

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Author information

Author/s: Furuhashi, Koichi (K); Kitoh, Junzoh (J); Tsukamura, Hiroko (H); Maeda, Kei-Ichiro (K); Wang, Hailan (H); Li, Weihua (W); Ichihara, Sahoko (S); Nakajima, Tamie (T); Ichihara, Gaku (G);

Affiliation: Department of Occupational and Environmental Health, Field of Social Life Science, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. fkoichi(-atsign-)med.nagoya-u.ac.jp

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Toxicology (Toxicology), published in Ireland. (Language: eng)

Reference: 2006-Jul; vol 224 (issue 3) : pp 219-28

Dates: Created 2006/07/10; Completed 2006/08/22; Revised 2006/11/15;

PMID: 16777312, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Administration, Inhalation
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Body Weight - drug effects
Dose-Response Relationship, Drug
Female
Hepatocytes - drug effects; pathology
Hydrocarbons, Brominated - administration & dosage; toxicity
Lactation
Litter Size - drug effects

Male
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Rats, Wistar
Reproduction - drug effects
Sexual Maturation - drug effects
Sperm Motility - drug effects
Survival Analysis
Testis - drug effects; pathology
Time Factors

Associated Chemicals: Hydrocarbons, Brominated (0) ; 1-bromopropane (106-94-5) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)

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