The effects of alpha2-adrenoceptor agents on anti-hyperalgesic effects of carbamazepine and oxcarbazepine in a rat model of inflammatory pain.

Full Abstract

In this study, the effects of yohimbine (alpha2-adrenoceptor antagonist) and clonidine (alpha2-adrenoceptor agonist) on anti-hyperalgesia induced by carbamazepine and oxcarbazepine in a rat model of inflammatory pain were investigated. Carbamazepine (10-40 mg/kg; i.p.) and oxcarbazepine (40-160 mg/kg; i.p.) caused a significant dose-dependent reduction of the paw inflammatory hyperalgesia induced by concanavalin A (Con A, intraplantarly) in a paw pressure test in rats. Yohimbine (1-3 mg/kg; i.p.) significantly depressed the anti-hyperalgesic effects of carbamazepine and oxcarbazepine, in a dose- and time-dependent manner. Both drug mixtures (carbamazepine-clonidine and oxcarbazepine-clonidine) administered in fixed-dose fractions of the ED50 (1/2, 1/4 and 1/8) caused significant and dose-dependent reduction of the hyperalgesia induced by Con A. Isobolographic analysis revealed a significant synergistic (supra-additive) anti-hyperalgesic effect of both combinations tested. These results indicate that anti-hyperalgesic effects of carbamazepine and oxcarbazepine are, at least partially, mediated by activation of adrenergic alpha2-receptors. In addition, synergistic interaction for anti-hyperalgesia between carbamazepine and clonidine, as well as oxcarbazepine and clonidine in a model of inflammatory hyperalgesia, was demonstrated.

Learn Faster Today Improve your study skills

Author information

Author/s: Vuckovic, Sonja M (SM); Tomic, Maja A (MA); Stepanovic-Petrovic, Radica M (RM); Ugresic, Nenad (N); Prostran, Milica S (MS); Boskovic, Bogdan (B);

Affiliation: Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia and Montenegro. svuckovic(-atsign-)med.bg.ac.yu

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Pain (Pain), published in Netherlands. (Language: eng)

Reference: 2006-Nov; vol 125 (issue 1-2) : pp 10-9

Dates: Created 2006/10/10; Completed 2006/11/08; Revised 2006/11/15;

PMID: 16777327, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analgesics, Non-Narcotic - administration & dosage
Animals
Carbamazepine - administration & dosage; analogs & derivatives
Concanavalin A
Disease Models, Animal
Dose-Response Relationship, Drug
Hyperalgesia - chemically induced; drug therapy; physiopathology

Hyperalgesia - chemically induced; drug therapy; physiopathology
Male
Pain Threshold - drug effects
Rats
Rats, Wistar
Receptors, Adrenergic, alpha-2 - agonists; antagonists & inhibitors
Treatment Outcome

Associated Chemicals: Analgesics, Non-Narcotic (0) ; Receptors, Adrenergic, alpha-2 (0) ; Concanavalin A (11028-71-0) ; oxcarbazepine (28721-07-5) ; Carbamazepine (298-46-4)

These are the highest related articles currently in the database:

See 100+ related articles.