Spatiotemporal analysis of the cortical sources of the steady-state visual evoked potential.

Full Abstract

This study aimed to characterize the neural generators of the steady-state visual evoked potential (SSVEP) to repetitive, 6 Hz pattern-reversal stimulation. Multichannel scalp recordings of SSVEPs and dipole modeling techniques were combined with functional magnetic resonance imaging (fMRI) and retinotopic mapping in order to estimate the locations of the cortical sources giving rise to the SSVEP elicited by pattern reversal. The time-varying SSVEP scalp topography indicated contributions from two major cortical sources, which were localized in the medial occipital and mid-temporal regions of the contralateral hemisphere. Colocalization of dipole locations with fMRI activation sites indicated that these two major sources of the SSVEP were located in primary visual cortex (V1) and in the motion sensitive (MT/V5) areas, respectively. Minor contributions from mid-occipital (V3A) and ventral occipital (V4/V8) areas were also considered. Comparison of SSVEP phase information with timing information collected in a previous transient VEP study (Di Russo et al. [2005] Neuroimage 24:874-886) suggested that the sequence of cortical activation is similar for steady-state and transient stimulation. These results provide a detailed spatiotemporal profile of the cortical origins of the SSVEP, which should enhance its use as an efficient clinical tool for evaluating visual-cortical dysfunction as well as an investigative probe of the cortical mechanisms of visual-perceptual processing.(c) 2006 Wiley-Liss, Inc.

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Author information

Author/s: Di Russo, Francesco (F); Pitzalis, Sabrina (S); Aprile, Teresa (T); Spitoni, Grazia (G); Patria, Fabiana (F); Stella, Alessandra (A); Spinelli, Donatella (D); Hillyard, Steven A (SA);

Affiliation: Department of Education in Sports and Human Movement, University of Motor Sciences (IUSM), Rome, Italy. fdirusso(-atsign-)iusm.it

Grants: EY-016984-32 (Agency:NEI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Human brain mapping (Hum Brain Mapp), published in United States. (Language: eng)

Reference: 2007-Apr; vol 28 (issue 4) : pp 323-34

Dates: Created 2007/03/20; Completed 2007/05/16; Revised 2007/12/03;

PMID: 16779799, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Brain Mapping
Electroencephalography
Evoked Potentials, Visual - physiology
Female
Functional Laterality - physiology

Functional Laterality - physiology
Humans
Magnetic Resonance Imaging
Male
Models, Neurological
Visual Cortex - physiology
Visual Perception - physiology

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