Research article summary (published 5 May 2006):

Hypoglycemic and antihyperglycemic activity of Aegle marmelos seed extract in normal and diabetic rats.

Full Abstract

Aegle marmelos Corr. (Rutaceae) is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. The aqueous extract of Aegle marmelos seeds was administered orally at different doses (100, 250 and 500 mg/kg) to normal as well as sub (fasting blood glucose (FBG) normal; glucose tolerance abnormal) and mild (FBG 120-250 mg/dl) diabetic rats. The dose of 250 mg/kg was found to be most effective dose and it decreases blood glucose level (BGL) by 35.1% in normal healthy rats after 6h of administration. The same dose also showed a marked reduction in BGL of 41.2% in sub and 33.2% in mild diabetic rats in glucose tolerance test (GTT) after 2 h. Treatment of severely (FBG >250 mg/dl) diabetic rats for 14 days with a dose of 250 mg/kg reduces the fasting blood glucose by 60.84% and urine sugar by 75% than their pretreatment levels. It brought about fall in level of total cholesterol (TC) by 25.49% with increase of 33.43% in high density lipoprotein (HDL) and decrease of 53.97 and 45.77% in low density lipoprotein (LDL) and triglyceride (TG), respectively. These results clearly indicate that aqueous seed extract of Aegle marmelos possess antidiabetic and hypolipidemic effects in diabetic rats.

Author information

Author/s: Kesari, Achyut Narayan (AN); Gupta, Rajesh Kumar (RK); Singh, Santosh Kumar (SK); Diwakar, Sandhya (S); Watal, Geeta (G);

Affiliation: Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad 211002, India.

Journal and publication information

Publication Type: Journal Article

Journal: Journal of ethnopharmacology (J Ethnopharmacol), published in Ireland. (Language: eng)

Reference: 2006-Oct; vol 107 (issue 3) : pp 374-9

Dates: Created 2006/09/15; Completed 2007/01/26;

PMID: 16781099, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aegle Animals Antilipemic Agents - pharmacology; therapeutic use; toxicity Blood Glucose - drug effects Carbohydrates - urine Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Diabetes Mellitus, Experimental - blood; drug therapy; urine Dose-Response Relationship, Drug Fasting - blood Glucose Tolerance Test Hyperglycemia - blood; drug therapy; urine

Hyperglycemia - blood; drug therapy; urine Hyperlipidemias - blood; drug therapy Hypoglycemic Agents - pharmacology; therapeutic use; toxicity Lethal Dose 50 Male Plant Extracts - pharmacology Rats Rats, Wistar Reference Values Seeds Severity of Illness Index Time Factors Triglycerides - blood

Associated Chemicals: Antilipemic Agents (0) ; Blood Glucose (0) ; Carbohydrates (0) ; Cholesterol, HDL (0) ; Cholesterol, LDL (0) ; Hypoglycemic Agents (0) ; Plant Extracts (0) ; Triglycerides (0) ; Cholesterol (57-88-5)

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