Unilateral lesion of the subthalamic nucleus enhances cortical fos expression associated with focally evoked seizures in the rat.

Full Abstract

Reducing subthalamic nucleus (STN) activity has been proposed as an anti-epileptic procedure. Here we show that, on the contrary, a unilateral lesion of the STN causes slight (nonsignificant) increases in the severity of limbic seizures evoked by bicuculline infusion into the piriform cortex, associated with marked Fos expression throughout the cerebral cortex. Abolishing the STN control over the basal ganglia output may therefore play a facilitatory role on cortical activation associated with limbic seizures.

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Author information

Author/s: Blandini, Fabio (F); Fancellu, Roberto (R); Armentero, Marie-Therese (MT); Tassorelli, Cristina (C); Greco, Rosaria (R); Fornai, Francesco (F); Nappi, Giuseppe (G);

Affiliation: Laboratory of Functional Neurochemistry, IRCCS Neurological Institute C. Mondino, Via Mondino, 2, 27100 Pavia, Italy. fabio.blandini(-atsign-)mondino.it

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Brain research (Brain Res), published in Netherlands. (Language: eng)

Reference: 2006-Jul; vol 1101 (issue 1) : pp 145-50

Dates: Created 2006/07/17; Completed 2006/09/19; Revised 2006/11/15;

PMID: 16782074, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Bicuculline - toxicity
Cerebral Cortex - metabolism; physiopathology
Convulsants - toxicity
Gene Expression Regulation - drug effects
Immunohistochemistry - methods
Male

Male
N-Methylaspartate - toxicity
Oncogene Proteins v-fos - metabolism
Rats
Rats, Sprague-Dawley
Seizures - chemically induced; metabolism; pathology
Subthalamic Nucleus - drug effects; injuries; pathology; physiopathology

Associated Chemicals: Convulsants (0) ; Oncogene Proteins v-fos (0) ; Bicuculline (485-49-4) ; N-Methylaspartate (6384-92-5)

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