Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study.

Full Abstract

In this study, a newly reported regional homogeneity approach was used to analyze blood oxygen level-dependent functional magnetic resonance imaging data on resting state in boys with attention deficit hyperactivity disorder. Boys with attention deficit hyperactivity disorder showed decreased regional homogeneity in the frontal-striatal-cerebellar circuits, but increased regional homogeneity mainly in the occipital cortex. Our findings are consistent with the hypothesis of abnormal frontal-striatal-cerebellar circuits in attention deficit hyperactivity disorder. The regional homogeneity approach may be a potentially useful method in exploring the pathophysiology of attention deficit hyperactivity disorder.

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Author information

Author/s: Cao, Qingjiu (Q); Zang, Yufeng (Y); Sun, Li (L); Sui, Manqiu (M); Long, Xiangyu (X); Zou, Qihong (Q); Wang, Yufeng (Y);

Affiliation: Institute of Mental Health, Peking University, Beijing, PR China.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuroreport (Neuroreport), published in England. (Language: eng)

Reference: 2006-Jul; vol 17 (issue 10) : pp 1033-6

Dates: Created 2006/06/22; Completed 2006/09/08; Revised 2006/11/15;

PMID: 16791098, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Attention Deficit Disorder with Hyperactivity - pathology; physiopathology
Brain - abnormalities; blood supply; pathology
Case-Control Studies
Child
Humans

Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging
Male
Oxygen - blood
Rest - physiology

Associated Chemicals: Oxygen (7782-44-7)

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