Mono-, Bi-, and triphenanthrenes from the tubers of Cremastra appendiculata.

Full Abstract

Six newphenanthrene derivatives, including three monophenanthrenes (1-3), two biphenanthrenes (4 and 5), and a triphenanthrene (6), have been isolated from an ethanolic extract of the tubers of Cremastra appendiculata. Using spectroscopic methods, the structures of compounds 1-6 were determined as 1-hydroxy-4,7-dimethoxy-1-(2-oxopropyl)-1H-phenanthren-2-one (1), 1,7-dihydroxy-4-methoxy-1-(2-oxopropyl)-1H-phenanthren-2-one (2), 2-hydroxy-4,7-dimethoxyphenanthrene (3), 2,7,2'-trihydroxy-4,4',7'-trimethoxy-1,1'-biphenanthrene (4), 2,2'-dihydroxy-4,7,4',7'-tetramethoxy-1,1'-biphenanthrene (5), and 2,7,2',7',2' '-pentahydroxy-4,4',4' ',7' '-tetramethoxy-1,8,1',1' '-triphenanthrene (6), respectively. Compounds 1-6 and two known compounds, cirrhopetalanthin (7) and flavanthrinin (8), obtained previously from this plant, were evaluated against six human cancer cells and a normal cell line.

Author information

Author/s: Xue, Zhen (Z); Li, Shuai (S); Wang, Sujuan (S); Wang, Yinhong (Y); Yang, Yongchun (Y); Shi, Jiangong (J); He, Lan (L);

Affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, People's Republic of China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of natural products (J Nat Prod), published in United States. (Language: eng)

Reference: 2006-Jun; vol 69 (issue 6) : pp 907-13

Dates: Created 2006/06/23; Completed 2006/07/31; Revised 2006/11/15;

PMID: 16792409, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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