Sublingual immunotherapy in the treatment of children.

Full Abstract

Children with controlled intermittent mild-to-moderate asthma, controlled rhinitis and a single sensitivity may be appropriate candidates for sublingual immunotherapy (SLIT). Positive effects of SLIT may depend on initiation in early childhood and a long duration of treatment. To ensure optimum compliance, sociological, economic and familial factors should also be taken in to consideration when prescribing SLIT. Evidence from recent long-term trials indicates that SLIT interfered with the atopic march and the allergic progression from rhinitis to asthma without any severe adverse side effects. Local immune response has been seen to be blunted with SLIT, which suggests that treatment has an immunomodulatory effect. In addition, it may also decrease the risk of new sensitizations. Ongoing developments in SLIT, particularly advances in dosing and new indications, such as food allergies, will increase the use of this treatment modality in children.

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Author information

Author/s: Pham-Thi, N (N); de Blic, J (J); Scheinmann, P (P);

Affiliation: Service de Pneumologie et Allergologie Pédiatriques, Hôpital Necker-Enfants Malades, Paris, France.

Journal and publication information

Publication Type: Journal Article; Review

Journal: Allergy (Allergy), published in Denmark. (Language: eng)

Reference: 2006-; vol 61 Suppl 81 (issue ) : pp 7-10

Dates: Created 2006/06/23; Completed 2006/11/13; Revised 2007/11/15;

PMID: 16792599, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Administration, Sublingual
Allergens - administration & dosage; immunology
Asthma - immunology; therapy
Child
Child, Preschool
Clinical Trials as Topic

Associated Chemicals: Allergens (0)

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