Research article summary (published 4 May 2006):

Differences in pharmacokinetic and electroencephalographic responses to caffeine in sleep-sensitive and non-sensitive subjects.

Full Abstract

The present study investigated pharmacokinetic and electroencephalographic responses to caffeine (140 mg) in two groups of healthy volunteers reporting, or not, caffeine-related sleep disturbances. Significant differences in caffeine consumption and smoking habits were observed between the two groups. Plasma samples were taken from each subject before (T0) and after caffeine intake at 0.5, 1, 2, 4, 6 and 24 h. Three pharmacokinetic parameters: half-life (t1/2), maximum time (Tmax) and maximum plasma concentration (Cmax) were calculated from caffeine plasma concentration measurements determined by reversed phase HPLC analysis. Caffeine-sensitive subjects showed significantly greater half-life values when calculated on 24 h after the administration than tolerant subjects (p<0.05). Since the elimination kinetics were similar on the first 6 h after caffeine administration, the increased caffeine clearance observed overnight, when smoking was resumed in the control group, may indicate a short delay for the induction of hepatic cytochrome, reported here for the first time. Electrophysiological responses to caffeine, including vigilance and cortical activity, were assessed by ambulatory electroencephalographic (EEG) recorded during a period of 6 h before and after caffeine consumption. Following caffeine intake, the caffeine-intolerant subjects presented an increase in vigilance levels with faster peak alpha, beta frequency and lower delta and theta power when compared to tolerant subjects. Pharmacokinetic parameters and EEG data showed significant differences between sleep-sensitive and control subjects. These variations may be, in part, explained by cigarette smoking and the higher caffeine intake observed in the subjects of the control groups while caffeine sleep-sensitive subjects have a significantly lower caffeine intake, as already reported in previous studies on patients with sleep disturbances.

Author information

Author/s: Bchir, Fatma (F); Dogui, Mohamed (M); Ben Fradj, Radhia (R); Arnaud, Maurice J (MJ); Saguem, Sâad (S);

Affiliation: Metabolic Biophysics and Applied Pharmacology Laboratory, Department of Biophysics, Medicine Faculty of Sousse, 4002 Sousse, Tunisia. tattou15tn(-atsign-)yahoo.fr

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Comptes rendus biologies (C R Biol), published in France. (Language: eng)

Reference: 2006-Jul; vol 329 (issue 7) : pp 512-9

Dates: Created 2006/06/26; Completed 2006/09/12; Revised 2007/11/15;

PMID: 16797457, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Beta Rhythm - drug effects Body Weight Caffeine - blood; pharmacokinetics; pharmacology Coffee Electroencephalography Half-Life

Half-Life Humans Male Middle Aged Questionnaires Sleep - drug effects; physiology Smoking

Associated Chemicals: Coffee (0) ; Caffeine (58-08-2)

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