High frequency oscillation and liquid ventilation.

Full Abstract

During high frequency oscillation ventilation (HFOV) small tidal volumes are delivered at fast frequencies, usually between 10 and 15 Hz. Meta-analysis of randomised trials of prophylactic HFOV versus conventional ventilation have demonstrated only a modest reduction in BPD amongst survivors in the HFOV groups. Similarly, no long term advantages of HFOV have been highlighted when it is used as rescue mode, but there have been few randomised studies. During liquid ventilation, the lungs are filled with perfluorocarbon, which, compared to water, has low surface tension and a high solubility for respiratory gases. Clinical experience of liquid ventilation is limited, but improvements in oxygenation and lung function have been shown in short term studies.

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Author information

Author/s: Greenough, Anne (A);

Affiliation: Division of Asthma, Allergy and Lung Biology, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, UK. anne.greenough(-atsign-)kcl.ac.uk

Journal and publication information

Publication Type: Journal Article; Review

Journal: Paediatric respiratory reviews (Paediatr Respir Rev), published in England. (Language: eng)

Reference: 2006-; vol 7 Suppl 1 (issue ) : pp S186-8

Dates: Created 2006/06/26; Completed 2006/10/31;

PMID: 16798558, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
High-Frequency Ventilation - methods
Humans
Infant, Newborn

Liquid Ventilation - methods
Respiratory Distress Syndrome, Newborn - complications; therapy
Respiratory Insufficiency - etiology; prevention & control
Treatment Outcome

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