Functional anatomy of the therapeutic effects of prism adaptation on left neglect.

Full Abstract

OBJECTIVE:
To investigate the anatomic substrates underlying the beneficial effect of prism adaptation in five patients with persistent left neglect following right stroke.

METHODS:
In a functional imaging PET study, we used a covariation analysis to examine linear changes of regional cerebral blood flow over sessions as a function of left neglect improvement.

RESULTS:
The network of significant brain regions associated with improvement of left neglect performance produced by prism adaptation involved the right cerebellum, the left thalamus, the left temporo-occipital cortex, the left medial temporal cortex, and the right posterior parietal cortex.

CONCLUSION:
Our results suggest that the realignment of visuomotor coordinates is processed by the cerebellum and that low level sensorimotor adaptation actively modulates cerebral areas, albeit now relying on intact cerebellocerebral connections. Hence, our data support the hypothesis that the beneficial effect of prism adaptation on the clinical presentation of left neglect derives from modulation of cortical regions implicated in spatial cognition.

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Author information

Author/s: Luauté, J (J); Michel, C (C); Rode, G (G); Pisella, L (L); Jacquin-Courtois, S (S); Costes, N (N); Cotton, F (F); le Bars, D (D); Boisson, D (D); Halligan, P (P); Rossetti, Y (Y);

Affiliation: INSERM Unité 534, Espace et Action, 16, Avenue du doyen Lépine, 69500 Bron, France.

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

Journal: Neurology (Neurology), published in United States. (Language: eng)

Reference: 2006-Jun; vol 66 (issue 12) : pp 1859-67

Dates: Created 2006/06/27; Completed 2006/07/19; Revised 2007/11/15;

PMID: 16801651, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adaptation, Physiological
Aged
Aged, 80 and over
Brain - blood supply; physiopathology; radionuclide imaging
Brain Mapping
Cerebrovascular Circulation
Female
Humans

Humans
Lenses
Male
Perceptual Disorders - etiology; physiopathology; radionuclide imaging; rehabilitation
Positron-Emission Tomography
Recovery of Function - physiology
Stroke - complications; physiopathology; radionuclide imaging; rehabilitation
Treatment Outcome

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