Viscoelastic measurements after vocal fold scarring in rabbits--short-term results after hyaluronan injection.

Full Abstract

CONCLUSIONS:
The scarring model resulted in significant damage and elevated viscoelasticity of the lamina propria. Hyaluronan preparations may alter viscoelasticity in scarred rabbit vocal folds.

OBJECTIVES:
Vocal fold scarring results in stiffness of the lamina propria and severe voice problems. The aims of this study were to examine the degree of scarring achieved in the experiment and to measure the viscoelastic properties after injection of hyaluronan in rabbit vocal folds.

MATERIALS AND METHODS:
Twenty-two vocal folds from 15 New Zealand rabbits were scarred, 8 vocal folds were controls. After 8 weeks 12 of the scarred vocal folds received injections with 2 types of cross-linked hyaluronan products and 10 scarred folds were injected with saline. After 11 more weeks the animals were sacrificed. After dissection, 15 vocal folds were frozen for viscoelastic measurements, whereas 14 vocal folds were prepared and stained. Measurements were made of the lamina propria thickness. Viscoelasticity was measured on intact vocal folds with a linear skin rheometer (LSR) adapted to laryngeal measurements.

RESULTS:
Measurements on the digitized slides showed a thickened lamina propria in the scarred samples as compared with the normal vocal folds (p<0.05). The viscoelastic analysis showed a tendency to stiffening of the scarred vocal folds as compared with the normal controls (p=0.05). There was large variation in stiffness between the two injected hyaluronan products.

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Author information

Author/s: Hertegård, S (S); Dahlqvist, A (A); Goodyer, E (E);

Affiliation: Department of Logopedics and Phoniatrics, Karolinska Institute, Huddinge University Hospital, Sweden. stellan.hertegard(-atsign-)klinvet.ki.se

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Acta oto-laryngologica (Acta Otolaryngol), published in Norway. (Language: eng)

Reference: 2006-Jul; vol 126 (issue 7) : pp 758-63

Dates: Created 2006/06/28; Completed 2006/11/28;

PMID: 16803717, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adjuvants, Immunologic - therapeutic use
Animals
Cicatrix - drug therapy
Disease Models, Animal
Elasticity - drug effects
Hyaluronic Acid - analogs & derivatives; therapeutic use

Hyaluronic Acid - analogs & derivatives; therapeutic use
Implants, Experimental
Laryngeal Mucosa
Rabbits
Viscosity - drug effects
Vocal Cords - drug effects; injuries; physiopathology

Associated Chemicals: Adjuvants, Immunologic (0) ; Restylane (0) ; hylan-B gel (0) ; Hyaluronic Acid (9004-61-9)

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