Human bocavirus: prevalence and clinical spectrum at a children's hospital.

Full Abstract

BACKGROUND:
Molecular methods of pathogen discovery have recently led to the description of several new respiratory viruses. Human bocavirus (HBoV), a proposed member of the family Parvoviridae, is one of the most recently described respiratory viruses. Initial reports indicate that HBoV is a common cause of respiratory tract infection in children.

METHODS:
A total of 1474 nasal scraping specimens collected over a 20-month period were screened by polymerase chain reaction for the presence of HBoV nucleic acid. Positive results were confirmed with a second polymerase chain reaction assay from a different genomic region. The medical records of patients with positive results were reviewed for demographic and clinical data.

RESULTS:
HBoV DNA was identified in 82 samples (5.6%). The peak rate of HBoV infection occurred during the period of March through May in both 2004 and 2005. Sixty-three percent of infected patients were <12 months of age. The most common symptoms were cough, rhinorrhea, and fever. Other symptoms of interest included diarrhea and a "paroxysmal" cough that was clinically suspected to be caused by Bordetella pertussis.

CONCLUSIONS:
HBoV DNA is commonly present in children with upper and lower respiratory tract infections. The presence of a pertussis-like cough and diarrhea in association with HBoV infection merits further investigation.

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Author information

Author/s: Arnold, John C (JC); Singh, Kumud K (KK); Spector, Stephen A (SA); Sawyer, Mark H (MH);

Affiliation: Department of Pediatrics, Division of Infectious Diseases and Center for AIDS Research, University of California, San Diego, CA 92123, USA. jcarnold(-atsign-)ucsd.edu

Grants: AI-36214 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis), published in United States. (Language: eng)

Reference: 2006-Aug; vol 43 (issue 3) : pp 283-8

Dates: Created 2006/06/28; Completed 2006/08/22; Revised 2007/11/14;

PMID: 16804840, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
California
Child
Child, Preschool
Female
Hospitals, Pediatric - statistics & numerical data
Humans
Infant
Infant, Newborn

Male
Mass Screening
Nose
Parvoviridae - isolation & purification
Parvoviridae Infections - virology
Polymerase Chain Reaction
Prevalence
Respiratory Tract Infections - virology
Retrospective Studies

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