Research article summary (published 25 Jun 2006):

Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease.

Full Abstract

BACKGROUND:
In aging mice, activity maintains hippocampal plasticity and adult hippocampal neurogenesis at a level corresponding to a younger age. Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD).

METHODS:
Amyloid precursor protein (APP)-23 mice were housed under standard or enriched conditions or in cages equipped with a running wheel. We assessed beta-amyloid plaque load, adult hippocampal neurogenesis, spatial learning, and mRNA levels of trophic factors in the brain.

RESULTS:
Despite stable beta-amyloid plaque load, enriched-living mice showed improved water maze performance, an up-regulation of hippocampal neurotrophin (NT-3) and brain-derived neurotrophic factor (BDNF) and increased hippocampal neurogenesis. In contrast, despite increased bodily fitness, wheel-running APP23 mice showed no change in spatial learning and no change in adult hippocampal neurogenesis but a down-regulation of hippocampal and cortical growth factors.

CONCLUSIONS:
We conclude that structural and molecular prerequisites for activity-dependent plasticity are preserved in mutant mice with an AD-like pathology. Our study might help explain benefits of activity for the aging brain but also demonstrates differences between physical and more cognitive activity. It also suggests a possible cellular correlate for the dissociation between structural and functional pathology often found in AD.

Learn Faster Today      Improve your study skills

Author information

Author/s: Wolf, Susanne A (SA); Kronenberg, Golo (G); Lehmann, Kathrin (K); Blankenship, Aaron (A); Overall, Rupert (R); Staufenbiel, Matthias (M); Kempermann, Gerd (G);

Affiliation: Max Delbrück Center for Molecular Medicine, Berlin-Buch, Charité University Medicine, Berlin, Germany.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Biological psychiatry (Biol Psychiatry), published in United States. (Language: eng)

Reference: 2006-Dec; vol 60 (issue 12) : pp 1314-23

Dates: Created 2006/12/12; Completed 2007/01/23;

PMID: 16806094, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alzheimer Disease - chemically induced; pathology; psychology Amyloid beta-Protein Precursor - toxicity Animals Brain - pathology Brain-Derived Neurotrophic Factor - biosynthesis; genetics Cell Count Cerebral Cortex - metabolism Cognition - physiology Disease Progression Environment Female Fibroblast Growth Factor 2 - biosynthesis

Fibroblast Growth Factor 2 - biosynthesis Hippocampus - metabolism Insulin-Like Growth Factor I - biosynthesis Maze Learning - physiology Mice Mice, Transgenic Motor Activity - physiology Nerve Growth Factor - biosynthesis; genetics Neurotrophin 3 - biosynthesis; genetics RNA, Messenger - biosynthesis; genetics Reverse Transcriptase Polymerase Chain Reaction Vascular Endothelial Growth Factor A - biosynthesis; genetics

Associated Chemicals: Amyloid beta-Protein Precursor (0) ; Brain-Derived Neurotrophic Factor (0) ; Neurotrophin 3 (0) ; RNA, Messenger (0) ; Vascular Endothelial Growth Factor A (0) ; Fibroblast Growth Factor 2 (103107-01-3) ; Insulin-Like Growth Factor I (67763-96-6) ; Nerve Growth Factor (9061-61-4)

Related articles

These are the highest related articles currently in the database:

• Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein. 13 May 2004
• Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease. 30 Oct 2000
• Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults. 29 Nov 2001
• Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease. 30 May 2008
• Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons. 29 Jun 2004
• Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease. 7 Apr 2005
• Mechanism of amyloid beta protein induced neuronal cell death: current concepts and future perspectives. 30 Dec 1996
• Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. 17 Nov 2007
• Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. 28 Nov 2007
• Examination of the interactions of the amyloid precursor protein carboxyl terminus to intracellular protein: possible role in apoptosis. 29 Jun 1999

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.