The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats.

Full Abstract

We recently reported that systemic injections of the mGluR(2/3) agonist LY379268, which decreases evoked glutamate release, attenuate context- and discrete cue-induced reinstatement of heroin seeking, but not heroin self-administration. Here, we report that systemic injections of LY379268 attenuate context- and discrete cue-induced reinstatement of sucrose seeking, but not sucrose self-administration. These results suggest that similar neuronal mechanisms mediate cue-induced relapse to opiate- and palatable food seeking.

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Author information

Author/s: Bossert, Jennifer M (JM); Poles, Gabriela C (GC); Sheffler-Collins, Sean I (SI); Ghitza, Udi E (UE);

Affiliation: Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. jbossert(-atsign-)intra.nida.nih.gov

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Intramural

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2006-Oct; vol 173 (issue 1) : pp 148-52

Dates: Created 2006/08/21; Completed 2006/10/12; Revised 2006/11/15;

PMID: 16834996, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amino Acids - pharmacology
Animals
Appetitive Behavior - drug effects
Behavior, Addictive - physiopathology
Bicyclo Compounds, Heterocyclic - pharmacology
Feeding Behavior - drug effects

Male
Rats
Receptors, Metabotropic Glutamate - agonists
Reinforcement (Psychology)
Self Administration
Sucrose - administration & dosage

Associated Chemicals: Amino Acids (0) ; Bicyclo Compounds, Heterocyclic (0) ; LY 379268 (0) ; Receptors, Metabotropic Glutamate (0) ; metabotropic glutamate receptor 2 (0) ; Sucrose (57-50-1)

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