Current management of reflex sympathetic dystrophy syndrome (complex regional pain syndrome type I).

Full Abstract

Although no major advances have occurred in the curative treatment of reflex sympathetic dystrophy syndrome (RSDS), new pathogenic insights may soon lead to innovative approaches, which may also prove effective in alleviating some forms of neuropathic pain. Preventing nerve compression and ischemia-reperfusion injury constitute valuable measures for preventing RSDS. Vitamin C administration can also prevent RSDS, together with clonidine in high-risk patients. Short-term glucocorticoid therapy has been found effective in preventing RSDS after stroke but has not been evaluated in other situations. Beneficial effects of bisphosphonates have been documented in several placebo-controlled trials. Placebo-controlled trials of ketamine and spinal cord stimulation are in order to confirm or refute the promising results obtained in open-label studies. Mirror visual feedback was introduced recently for the rehabilitation of patients with RSDS but needs to be evaluated in randomized controlled trials.

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Author information

Author/s: Berthelot, Jean-Marie (JM);

Affiliation: Service de rhumatologie, Hôtel-Dieu, CHU de Nantes, 1, place Alexis, Nantes cedex 01, France. jeanmarie.berthelot(-atsign-)chu-nantes.fr

Journal and publication information

Publication Type: Journal Article; Review

Journal: Joint, bone, spine : revue du rhumatisme (Joint Bone Spine), published in France. (Language: eng)

Reference: 2006-Oct; vol 73 (issue 5) : pp 495-9

Dates: Created 2006/10/02; Completed 2006/10/26;

PMID: 16837228, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analgesics - therapeutic use
Diphosphonates - therapeutic use
Feedback
Humans

Humans
Reflex Sympathetic Dystrophy - drug therapy; prevention & control
Sympatholytics - therapeutic use
Vitamins - therapeutic use

Associated Chemicals: Analgesics (0) ; Diphosphonates (0) ; Sympatholytics (0) ; Vitamins (0)

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