Environmental tobacco smoke and mortality in Chinese women who have never smoked: prospective cohort study.

Full Abstract

OBJECTIVE:
To evaluate the association of environmental exposure to tobacco smoke from husbands and from work, as well as from family members in early life, with all cause mortality and mortality due to cancer or cardiovascular disease in Chinese women.

DESIGN:
Ongoing prospective cohort study in Shanghai, China.

PARTICIPANTS:
Of 72,829 women who had never smoked, 65,180 women provided information on smoking by their husbands, and 66,520 women provided information on exposure to tobacco smoke at work and in early life from family members.

MAIN OUTCOME MEASURES:
All cause mortality and cause specific mortality with the main focus on cancer and cardiovascular disease. Cumulative mortality according to exposure status, and hazard ratios.

RESULTS:
Exposure to tobacco smoke from husbands (mainly current exposure) was significantly associated with increased all cause mortality (hazard ratio 1.15, 95% confidence interval 1.01 to 1.31) and with increased mortality due to cardiovascular disease (1.37, 1.06 to 1.78). Exposure to tobacco smoke at work was associated with increased mortality due to cancer (1.19, 0.94 to 1.50), especially lung cancer (1.79, 1.09 to 2.93). Exposure in early life was associated with increased mortality due to cardiovascular disease (1.26, 0.94 to 1.69).

CONCLUSIONS:
In Chinese women, exposure to environmental tobacco smoke is related to moderately increased risk of all cause mortality and mortality due to lung cancer and cardiovascular disease.

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Author information

Author/s: Wen, Wanqing (W); Shu, Xiao Ou (XO); Gao, Yu-Tang (YT); Yang, Gong (G); Li, Qi (Q); Li, Honglan (H); Zheng, Wei (W);

Affiliation: Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. wanqing.wen(-atsign-)vanderbilt.edu

Grants: R01CA70867 (Agency:NCI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: BMJ (Clinical research ed.) (BMJ), published in England. (Language: eng)

Reference: 2006-Aug; vol 333 (issue 7564) : pp 376

Dates: Created 2006/08/18; Completed 2006/08/25; Revised 2008/11/20;

PMID: 16837487, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Aged
Cardiovascular Diseases - mortality
Cause of Death
China - epidemiology
Cohort Studies
Female
Humans
Lung Neoplasms - mortality

Middle Aged
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Factors
Spouses - statistics & numerical data
Tobacco Smoke Pollution - statistics & numerical data
Urban Health
Women's Health

Associated Chemicals: Tobacco Smoke Pollution (0)

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