Is implicit sequence learning impaired in Parkinson's disease? A meta-analysis.

Full Abstract

The aim of the present study was to examine impairment of implicit learning in Parkinson's disease (PD) by means of a meta-analysis of studies that used the serial reaction time (SRT) task. The authors performed a systematic review and meta-analysis of published journal articles (1987-2005) that used the SRT task with patients with PD. The principal outcome measures used to compare studies were (a) the difference in reaction time between the last block of ordered sequence trials and the randomized block for PD and control participants and (b) fixed and random effects pooled estimates by the inverse weighting method. Six studies, including 67 patients with PD, met the inclusion criteria. The meta-analysis showed that implicit learning was impaired in PD, relative to healthy controls, with a standardized mean difference of 0.73 (95% confidence interval = 0.38, 1.07). Implicit sequence learning appears to be impaired in patients with PD. Some common methodological weaknesses and limitations in the reporting of statistical data are discussed.((c) 2006 APA, all rights reserved).

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Author information

Author/s: Siegert, Richard J (RJ); Taylor, Kathryn D (KD); Weatherall, Mark (M); Abernethy, David A (DA);

Affiliation: Department of Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington South, New Zealand. rsiegert(-atsign-)wnmeds.ac.nz

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Neuropsychology (Neuropsychology), published in United States. (Language: eng)

Reference: 2006-Jul; vol 20 (issue 4) : pp 490-5

Dates: Created 2006/07/18; Completed 2006/09/19; Revised 2007/11/15;

PMID: 16846267, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Aged, 80 and over
Confidence Intervals
Female
Humans
Learning Disorders - physiopathology
Male

Meta-Analysis as Topic
Middle Aged
Neuropsychological Tests - statistics & numerical data
Parkinson Disease - physiopathology
Reaction Time - physiology
Review Literature as Topic
Serial Learning - physiology

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