Epidemiology of Hoffmeister's "genetically determined predisposition to disturbed development of the dentition" in patients with cleft lip and palate.

Full Abstract

OBJECTIVE:
Type and prevalence rates of the symptoms of Hoffmeister's "genetically determined predisposition to disturbed development of the dentition" were studied in patients with clefts.

PATIENTS:
Data of 263 patients with nonsyndromic clefts of lip (alveolus and palate) or isolated cleft palates were examined in a retrospective study.

SETTING:
The clefts were classified as cleft lip or cleft lip and alveolus, cleft palate, unilateral cleft lip and palate, and bilateral cleft lip and palate. All patients were scrutinized for 28 individual symptoms. Prevalences of the individual symptoms were statistically evaluated regarding cleft type and gender by using the chi-square test and were also compared with findings in patients without clefts.

RESULTS:
In 97.7% of the patients with clefts, at least one symptom was found. Microdontia of individual teeth, hypodontia, and hyperodontia were the symptoms most frequently recorded. Comparison of the different cleft types revealed differences regarding the prevalences of supernumerary lateral incisors (p = .051), infraposition of deciduous molars (p < .001), and atypical tooth bud position (p = .030). Comparison of the prevalences of 10 symptoms recorded in the patients with clefts with the prevalences recorded in patients without clefts showed nine symptoms were found much more frequently in the population with clefts.

CONCLUSION:
These findings support the hypothesis that clefting is part of a complex malformation associated with other dental anomalies resulting from disturbed development of the dentition. Patients with clefts are also likely to present other deficiencies of dental development and tooth eruption in both dentitions, even in regions not affected by the cleft.

Learn Faster Today Improve your study skills

Author information

Author/s: Stahl, Franka (F); Grabowski, Rosemarie (R); Wigger, Katrin (K);

Affiliation: Department of Orthodontics, University of Rostock, Rostock, Germany. Franka.Stahl(-atsign-)medizin.uni-rostock.de

Journal and publication information

Publication Type: Journal Article

Journal: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association (Cleft Palate Craniofac J), published in United States. (Language: eng)

Reference: 2006-Jul; vol 43 (issue 4) : pp 457-65

Dates: Created 2006/07/20; Completed 2006/09/19;

PMID: 16854204, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Chi-Square Distribution
Child
Child, Preschool
Cleft Lip - complications
Cleft Palate - complications
Female

Genetic Predisposition to Disease - epidemiology
Humans
Infant
Male
Prevalence
Retrospective Studies
Tooth Abnormalities - epidemiology; etiology

These are the highest related articles currently in the database:

See 100+ related articles.