Sirtuins in aging and age-related disease.

Full Abstract

Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are regulated by the cofactor NAD and thus may serve as sensors of the metabolic state of the cell and organism. Here we examine the roles of Sirtuins in diverse eukaryotic species, with special emphasis on their links to aging and age-related diseases including cancer, diabetes, and neurodegenerative disorders.

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Author information

Author/s: Longo, Valter D (VD); Kennedy, Brian K (BK);

Affiliation: Department of Molecular and Computational Biology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA. vlongo(-atsign-)usc.edu

Grants: AG01028 (Agency:NIA NIH HHS) ; AG20642 (Agency:NIA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: Cell (Cell), published in United States. (Language: eng)

Reference: 2006-Jul; vol 126 (issue 2) : pp 257-68

Dates: Created 2006/07/28; Completed 2006/09/06; Revised 2007/11/14;

PMID: 16873059, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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