Ophthalmic findings in apert syndrome prior to craniofacial surgery.

Full Abstract

PURPOSE: To determine ophthalmic findings in patients with Apert syndrome before craniofacial surgery. DESIGN: A cross-sectional retrospective study. METHODS: Review of 63 cases (27 males, 36 females) with Apert syndrome without craniofacial surgery from the Australian Craniofacial Unit. Demographic data, age of presentation, and ophthalmic findings at the first presentation were recorded. RESULTS: At a mean age of four years and median age of one year, at least 14% of patients had amblyopia, 60% of patients had strabismus, 19% of patients had anisometropia, and 34% of eyes had ametropia. Exposure keratopathy and corneal scarring occurred in at least 13% of patients and optic atrophy in at least 8% of patients. CONCLUSIONS: This study demonstrated that patients with Apert syndrome were at risk of amblyopia because of high prevalence of refractive errors, strabismus, and anisometropia. Exposure keratopathy and corneal scarring occurred commonly.

Author information

Author/s: Khong, Jwu Jin (JJ); Anderson, Peter (P); Gray, Timothy L (TL); Hammerton, Michael (M); Selva, Dinesh (D); David, David (D);

Affiliation: Oculoplastic and Orbital Division, Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, Australia. jjkhong(-atsign-)yahoo.com

Journal and publication information

Publication Type: Journal Article

Journal: American journal of ophthalmology (Am J Ophthalmol), published in United States. (Language: eng)

Reference: 2006-Aug; vol 142 (issue 2) : pp 328-30

Dates: Created 2006/07/31; Completed 2006/08/29;

PMID: 16876521, status: MEDLINE (last retrieved date: 2/18/2009)

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