Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models.

Full Abstract

Extracts of Ginkgo biloba (EGB) are a complex product prepared from green leaves of the Ginkgo biloba tree. In the present study, the antidepressant effect of EGB was examined using two behavioral models, the forced swimming test (FST) in rats and tail suspension test (TST) in mice. EGB significantly reduced immobility time in the FST at a dosage of 10 and 50 mg/kg body weight after repeated oral treatment for 14 d, although no change of motor dysfunction was observed with the same dosage in the open field test. These results indicate that EGB might possess an antidepressant activity. In addition, EGB markedly shortened immobility time in the TST after acute inter-peritoneal treatment at a dosage of 50 and 100 mg/kg body weight. The present study clearly demonstrated that EGB exerts an antidepressant effect in these two behavioral models.

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Author information

Author/s: Sakakibara, Hiroyuki (H); Ishida, Kaori (K); Grundmann, Oliver (O); Nakajima, Jun-ichiro (J); Seo, Shujiro (S); Butterweck, Veronika (V); Minami, Yuko (Y); Saito, Satomi (S); Kawai, Yoshichika (Y); Nakaya, Yutaka (Y); Terao, Junji (J);

Affiliation: Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull), published in Japan. (Language: eng)

Reference: 2006-Aug; vol 29 (issue 8) : pp 1767-70

Dates: Created 2006/08/01; Completed 2006/10/18; Revised 2006/11/15;

PMID: 16880641, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Antidepressive Agents - pharmacology
Behavior, Animal - drug effects
Ginkgo biloba - chemistry
Locomotion - drug effects
Male

Male
Mice
Mice, Inbred C57BL
Plant Extracts - pharmacology
Plant Leaves - chemistry
Rats

Associated Chemicals: Antidepressive Agents (0) ; Plant Extracts (0)

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