Genetic predictors for acute experimental cold and heat pain sensitivity in humans.

Full Abstract

BACKGROUND:
The genetic contribution to pain sensitivity underlies a complex composite of parallel pain pathways, multiple mechanisms, and diverse inter-individual pain experiences and expectations.

METHODS:
Variations for genes encoding receptors related to cold and heat sensation, such as transient receptor potential A subtype 1 (TRPA1), M subtype 8 (TRPM8), V subtype 1 (TRPV1), delta opioid receptor subtype 1 (OPRD1), catechol O-methyltransferase (COMT), and fatty acid amide hydrolyase (FAAH), were investigated in four major ethnic populations.

RESULTS:
We defined 13 haplotype blocks in European Americans, seven blocks in African Americans, seven blocks in Hispanic subjects, and 11 blocks in Asian Americans. Further study in European American subjects found significant associations between short duration cold pain sensitivity and variations in TRPA1, COMT, and FAAH in a gender dependent manner. Our observations demonstrate that genetic variations in TRPA1, COMT, and FAAH contribute gender specifically to individual variations in short duration cold pain sensitivity in a European American cohort.

CONCLUSIONS:
The effects of TRPA1 variations on experimental short duration heat pain sensitivity may contribute to inter-individual variation in pain sensitivity in humans.

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Author information

Author/s: Kim, H (H); Mittal, D P (DP); Iadarola, M J (MJ); Dionne, R A (RA);

Journal and publication information

Publication Type: Letter; Research Support, N.I.H., Intramural

Journal: Journal of medical genetics (J Med Genet), published in England. (Language: eng)

Reference: 2006-Aug; vol 43 (issue 8) : pp e40

Dates: Created 2006/08/02; Completed 2006/12/27; Revised 2008/11/21;

PMID: 16882734, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amidohydrolases - genetics
Calcium Channels - genetics
Cold Temperature
European Continental Ancestry Group - genetics
Female
Genome, Human - genetics
Haplotypes - genetics
Hot Temperature
Humans
Linkage Disequilibrium - genetics

Male
N-Ethylmaleimide-Sensitive Proteins - genetics
Nerve Tissue Proteins - genetics
Pain - genetics
Pain Threshold - physiology
Polymorphism, Single Nucleotide - genetics
Receptors, Opioid, delta - genetics
TRPM Cation Channels - genetics
TRPV Cation Channels - genetics
Transient Receptor Potential Channels - genetics

Associated Chemicals: Calcium Channels (0) ; Nerve Tissue Proteins (0) ; Receptors, Opioid, delta (0) ; TRPA1 protein, human (0) ; TRPM Cation Channels (0) ; TRPM8 protein, human (0) ; TRPV Cation Channels (0) ; TRPV1 protein, human (0) ; Transient Receptor Potential Channels (0) ; Amidohydrolases (EC 3.5.-) ; fatty-acid amide hydrolase (EC 3.5.1.-) ; N-Ethylmaleimide-Sensitive Proteins (EC 3.6.4.6)

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