CREB antisense oligodeoxynucleotide administration into the dorsal hippocampal CA3 region impairs long- but not short-term spatial memory in mice.

Full Abstract

The transcription factor cAMP response-element binding protein (CREB) has a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent long-term memory. We recently demonstrated that the dorsal hippocampal CA3 region is involved in memory consolidation of spatial information tested on a Morris water maze in mice. To test whether activation of CREB in the CA3 region is required for memory consolidation of spatial information, bilaterally cannulated mice were infused 18 h before the beginning of the behavioral training with antisense or control sense CREB oligodeoxynucleotides (ODNs) or buffer. Mice were then subjected to massed training in a spatial version of the water maze and tested for retention 0 or 24 h after the last training session. We showed that CREB antisense ODN-infusion in the CA3 region impaired long-term memory when tested 24 h later but had no effect on spatial acquisition or short-term memory tested immediately after behavioral training. These findings provide evidence that the regionally restricted activation of CREB in the dorsal hippocampal CA3 region is critical for the long-term memory consolidation phase of spatial learning but not for short-term memory.

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Author information

Author/s: Florian, Cédrick (C); Mons, Nicole (N); Roullet, Pascal (P);

Affiliation: Centre de Recherches sur la Cognition Animale, Centre National de la Recherche Scientifique, Unité Mixte de Recherche, CNRS UMR, 5169, Université Paul Sabatier, 31062 Toulouse cedex 9, France.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Learning & memory (Cold Spring Harbor, N.Y.) (Learn Mem), published in United States. (Language: eng)

Reference: -2006 Jul-Aug; vol 13 (issue 4) : pp 465-72

Dates: Created 2006/08/02; Completed 2006/10/04; Revised 2008/11/20;

PMID: 16882863, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Cyclic AMP Response Element-Binding Protein - genetics; physiology
Female
Hippocampus - drug effects; physiology
Immunohistochemistry
Male

Memory - drug effects; physiology
Memory, Short-Term - physiology
Mice
Mice, Inbred C57BL
Oligodeoxyribonucleotides, Antisense - pharmacology
Space Perception - drug effects; physiology

Associated Chemicals: Creb1 protein, mouse (0) ; Cyclic AMP Response Element-Binding Protein (0) ; Oligodeoxyribonucleotides, Antisense (0)

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