Language dominance in mesial temporal lobe epilepsy: a functional transcranial Doppler sonography study of brain plasticity.

Full Abstract

Functional transcranial Doppler sonography was used to study hemispheric language dominance (HLD) in 24 right-handed patients with left temporal lobe epilepsy (TLE) and a structural lesion in the left temporal lobe and in 69 healthy controls. Twenty-five percent of the patients and 4% of controls showed atypical (right or bilateral) HLD. Degree of HLD was not correlated with age, Full Scale IQ, Verbal IQ, spike frequency, seizure frequency, age at seizure onset, or duration of TLE. Atypical HLD appears to be lesion-induced, independent of epilepsy characteristics.

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Author information

Author/s: Knake, Susanne (S); Haag, Anja (A); Pilgramm, Guido (G); Dittmer, Christine (C); Reis, Janine (J); Assmann, Heike (H); Oertel, Wolfgang H (WH); Rosenow, Felix (F); Hamer, Hajo M (HM);

Affiliation: Interdisciplinary Epilepsy Center, Department of Neurology, Philipps University, Rudolf-Bultmann-Strasse 8, 35033 Marburg, Germany. knake(-atsign-)staff.uni-marburg.de

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Epilepsy & behavior : E&B (Epilepsy Behav), published in United States. (Language: eng)

Reference: 2006-Sep; vol 9 (issue 2) : pp 345-8

Dates: Created 2006/09/04; Completed 2006/10/18; Revised 2006/11/15;

PMID: 16890495, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Case-Control Studies
Dominance, Cerebral
Epilepsy, Temporal Lobe - physiopathology; surgery; ultrasonography
Female
Hippocampus - physiopathology
Humans

Language
Male
Middle Aged
Neuronal Plasticity
Preoperative Care
Reference Values
Sclerosis
Ultrasonography, Doppler, Transcranial

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