Relation of low-grade inflammation and endothelial activation to blood pressure in obese children and adolescents.

Full Abstract

OBJECTIVE:
To determine the role of low-grade, systemic inflammation and endothelial activation in the modulation of blood pressure (BP) independently of other traditional risk factors in obese children and adolescents.

DESIGN:
We surveyed 281 obese subjects, aged 6-18 years to investigate the relationship of serum inflammation and endothelial activation markers and blood pressure.

MEASUREMENTS:
Clinical variables, indices of obesity, ambulatory 24-h blood pressure and serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), glucose and insulin. HOMA IR was used as a marker of insulin resistance (IR).

RESULTS:
CRP, IL-6, IL-1 beta, and ICAM-1 correlated significantly with mean 24-h systolic BP, whereas CRP and IL-6 was positively correlated with mean 24-h diastolic BP. Multiple regression analysis showed that serum IL-6 (P < .001) concentration, HOMA IR (P < .01), and waist to hip ratio (P < .05) were the significant determinants of systolic BP, whereas CRP (P < .05) level was the only predictor of diastolic BP. There were no significant associations of cell adhesion molecules with BP.

CONCLUSIONS:
These results indicate that low-grade inflammation may play a role in the modulation of arterial BP relatively early in life.

Learn Faster Today Improve your study skills

Author information

Author/s: Syrenicz, Anhelli (A); Garanty-Bogacka, Barbara (B); Syrenicz, Malgorzata (M); Gebala, Aneta (A); Dawid, Grazyna (G); Walczak, Mieczyslaw (M);

Affiliation: Department of Endocrinology, Arterial Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland. anhelli(-atsign-)asymed.ifg.pl

Journal and publication information

Publication Type: Journal Article

Journal: Neuro endocrinology letters (Neuro Endocrinol Lett), published in Sweden. (Language: eng)

Reference: 2006-Aug; vol 27 (issue 4) : pp 459-64

Dates: Created 2006/12/12; Completed 2007/02/12;

PMID: 16891995, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Biological Markers - blood
Blood Glucose
Blood Pressure - immunology
C-Reactive Protein - metabolism
Child
Endothelium, Vascular - immunology
Female
Humans
Inflammation - epidemiology; immunology; physiopathology

Insulin - blood
Insulin Resistance - immunology
Intercellular Adhesion Molecule-1 - blood
Interleukin-1beta - blood
Interleukin-6 - blood
Male
Obesity - epidemiology; immunology; physiopathology
Predictive Value of Tests
Risk Factors
Vascular Cell Adhesion Molecule-1 - blood

Associated Chemicals: Biological Markers (0) ; Blood Glucose (0) ; Interleukin-1beta (0) ; Interleukin-6 (0) ; Vascular Cell Adhesion Molecule-1 (0) ; Insulin (11061-68-0) ; Intercellular Adhesion Molecule-1 (126547-89-5) ; C-Reactive Protein (9007-41-4)

These are the highest related articles currently in the database:

See 100+ related articles.