Low-grade systemic inflammation and the risk of type 2 diabetes in obese children and adolescents.

Full Abstract

BACKGROUND:
There is growing evidence that low-grade systemic inflammation is closely involved in the pathogenesis of type 2 diabetes.

OBJECTIVE:
The aim of this study was to investigate the relationship between serum inflammatory markers and selected parameters known as risk factors of type 2 diabetes in obese children and adolescents.

SUBJECTS AND METHODS:
Fasting levels of C-reactive protein (CRP), fibrinogen (FB) interleukin-6 (IL-6), interleukin 1-beta (IL-1beta), glucose, insulin, total, HDL and LDL cholesterol, triglycerides, white blood cell count (WBC) and fasting glucose to insulin ratio (FGIR) were measured in 281 obese children and adolescents. Pearson's correlation was used for assessing the relationship between inflammatory markers and selected clinical parameters.

RESULTS:
Inflammatory markers correlated significantly with insulin resistance indices, HbA1c, lipid profile, hypertension, positive family history of type 2 diabetes, low physical fitness, and mixed high-fat and high-carbohydrate diet.

CONCLUSIONS:
Serum inflammatory markers were significantly correlated with most factors implicated in the development of type 2 diabetes. These data provide additional support for previously reported in adults relationship between subclinical inflammation and the risk of type 2 diabetes.

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Author information

Author/s: Syrenicz, Anhelli (A); Garanty-Bogacka, Barbara (B); Syrenicz, Malgorzata (M); Gebala, Aneta (A); Walczak, Mieczyslaw (M);

Affiliation: Department of Endocrinology, Arterial Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland. anhelli(-atsign-)asymed.ifg.pl

Journal and publication information

Publication Type: Journal Article

Journal: Neuro endocrinology letters (Neuro Endocrinol Lett), published in Sweden. (Language: eng)

Reference: 2006-Aug; vol 27 (issue 4) : pp 453-8

Dates: Created 2006/12/12; Completed 2007/02/12;

PMID: 16892000, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Biological Markers - blood
Blood Glucose
C-Reactive Protein - metabolism
Child
Child, Preschool
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diabetes Mellitus, Type 2 - epidemiology; immunology; metabolism
Female
Fibrinogen - metabolism

Fibrinogen - metabolism
Humans
Inflammation - epidemiology; metabolism
Insulin - blood
Interleukin-1beta - blood
Interleukin-6 - blood
Leukocyte Count
Male
Obesity - epidemiology; immunology; metabolism
Risk Factors
Triglycerides - blood

Associated Chemicals: Biological Markers (0) ; Blood Glucose (0) ; Cholesterol, HDL (0) ; Cholesterol, LDL (0) ; Interleukin-1beta (0) ; Interleukin-6 (0) ; Triglycerides (0) ; Insulin (11061-68-0) ; Fibrinogen (9001-32-5) ; C-Reactive Protein (9007-41-4)

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