Individual differences in the effect of novel environmental stimuli prior to amphetamine self-administration in rats (Rattus norvegicus).

Full Abstract

These experiments determined whether individual differences in response to novelty subsequently predict the ability of novel stimuli, presented prior to the session, to decrease amphetamine self-administration. Using an inescapable locomotor test, the authors found that high-responder rats (Rattus norvegicus) showed a greater novelty-induced decrease in the acquisition of self-administration compared with low-responder rats. This effect was dose dependent and generalized to sucrose-reinforced responding. Using a free-choice place preference test, the authors found that high-novelty-seeking rats also showed a greater novelty-induced decrease in the acquisition of self-administration compared with low-novelty- seeking rats. Regardless of individual differences, novelty had little effect on amphetamine self-administration during the maintenance phase. These results suggest that exposure to novel environmental stimuli may reduce acquisition of drug-taking behavior, especially among high-novelty-seeking individuals.

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Author information

Author/s: Cain, Mary E (ME); Dotson, William F (WF); Bardo, Michael T (MT);

Affiliation: Department of Psychology, University of Kentucky, KY 66506, USA. mecain(-atsign-)ksu.edu

Grants: F32 DA16013 (Agency:NIDA NIH HHS) ; P50 DA05312 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Experimental and clinical psychopharmacology (Exp Clin Psychopharmacol), published in United States. (Language: eng)

Reference: 2006-Aug; vol 14 (issue 3) : pp 389-401

Dates: Created 2006/08/08; Completed 2006/12/05; Revised 2007/12/03;

PMID: 16893281, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amphetamines - administration & dosage
Animals
Male
Motivation

Associated Chemicals: Amphetamines (0)

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