Ethological comparison of the effects of a bovine alpha s1-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety.

Full Abstract

A bovine alpha s1-casein tryptic hydrolysate was previously demonstrated to display an anxiolytic-like activity in the conditioned defensive burying and in the elevated plus-maze models when i.p. injected. The present study assessed the anxiolytic-like effects of this tryptic hydrolysate after an oral administration in rats faced to the same behavioural situations using diazepam as a reference. In a first experiment, the behavioural effects of the hydrolysate in the conditioned defensive burying test were investigated at doses ranging 5-50 mg/kg. The results showed that the minimal dose required to elicit an anxiolytic-like activity is 15 mg/kg. In a second experiment, the alpha s1-casein tryptic hydrolysate (15 mg/kg, p.o.) was demonstrated to display an anxiolytic-like activity similar to diazepam (3 mg/kg, p.o.) in the conditioned defensive burying test and the elevated plus-maze. However, the ethological analysis of behaviour indicated that this hydrolysate has a different activity compared to diazepam. While diazepam induced a disinhibition state in rats, possibly related to the risk-taking behaviour observed after a benzodiazepine ingestion in humans, the tryptic hydrolysate did not display such a side effect. These results suggest that the mechanism of action of the bovine alpha s1-casein tryptic hydrolysate may differ from that of diazepam.

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Author information

Author/s: Violle, Nicolas (N); Messaoudi, Michaël (M); Lefranc-Millot, Catherine (C); Desor, Didier (D); Nejdi, Amine (A); Demagny, Benoit (B); Schroeder, Henri (H);

Affiliation: Neurosciences Comportementales, URAFPA, INRA UC12340, INPL-UHP, 54500 Vandoeuvre-lès-Nancy, France.

Journal and publication information

Publication Type: Journal Article

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in United States. (Language: eng)

Reference: 2006-Jul; vol 84 (issue 3) : pp 517-23

Dates: Created 2006/09/04; Completed 2006/12/18;

PMID: 16899284, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Anti-Anxiety Agents - pharmacology
Anxiety - drug therapy
Behavior, Animal
Caseins - pharmacology
Cattle
Conditioning, Classical
Diazepam - pharmacology

Diazepam - pharmacology
Dose-Response Relationship, Drug
Male
Maze Learning - drug effects
Rats
Rats, Wistar
Risk
Trypsin - chemistry; pharmacology

Associated Chemicals: Anti-Anxiety Agents (0) ; Caseins (0) ; Diazepam (439-14-5) ; casein hydrolysate (65072-00-6) ; Trypsin (EC 3.4.21.4)

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