Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain.

Full Abstract

Ginkgo biloba from the traditional Chinese system of medicine has been found to possess neurocognitive enhancing effects. The mechanism of action of Ginkgo seems to be related to its antioxidant properties. In the present study, Ginkgo biloba phytosomes were administered to Wistar rats at 50 mg/kg and 100 mg/kg for 7 and 14 days. Chemical hypoxia was induced by administration of sodium nitrite (75 mg/kg) 1 h after the last administration of treatment. Thirty minutes after sodium nitrite administration, the animals were killed and the cerebral cortex, cerebellum, hippocampus and striatum were isolated and homogenized. The supernatants were used for the estimation of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. Ginkgo biloba phytosome treatment was found to increase superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities in all the brain regions compared with those treated only with sodium nitrite. The prevention of depletion of the antioxidant enzymes by sodium nitrite in the presence of Ginkgo biloba phytosomes may be correlated to its antioxidant activity.Copyright (c) 2006 John Wiley & Sons, Ltd.

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Author information

Author/s: Naik, Suresh R (SR); Pilgaonkar, Vinaya W (VW); Panda, Vandana S (VS);

Affiliation: Department of Pharmacology and Toxicology, Principal K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgankar Marg, Cuffe Parade, Colaba, Mumbai 400 005, India. srnaik5(-atsign-)rediffmail.com

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Phytotherapy research : PTR (Phytother Res), published in England. (Language: eng)

Reference: 2006-Nov; vol 20 (issue 11) : pp 1013-6

Dates: Created 2006/10/26; Completed 2007/01/26;

PMID: 16909446, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Antioxidants - pharmacology
Brain - drug effects; enzymology
Drugs, Chinese Herbal - pharmacology
Female
Ginkgo biloba - chemistry

Male
Oxidoreductases - analysis; drug effects
Plant Extracts - pharmacology
Rats
Rats, Wistar
Sodium Nitrite - administration & dosage

Associated Chemicals: Antioxidants (0) ; Drugs, Chinese Herbal (0) ; Plant Extracts (0) ; Sodium Nitrite (7632-00-0) ; Oxidoreductases (EC 1.-)

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