Sarcoidosis in residents of northern Israel of Arabic and Jewish origin: a comparative study.

Full Abstract

BACKGROUND:
This study describes the features of sarcoidosis among Arab patients and compares it to Jewish patients residing in northern Israel.

METHODS:
All new cases of biopsy-confirmed sarcoidosis diagnosed between 1980 and 1996 in northern Israel were divided into two groups according to their ethnic origin:
Jewish (n = 72) and Arabic (n = 48). Disease parameters were recorded and compared.

RESULTS:
Arabs and Jews had similar incidence rates that increased from 0.2/10(5) in 1980 to 2/10(5) per year in 1996. The peak incidence was in the sixth and seventh decades and the female/male ratio was 2 and 1.4 for Arabic and Jewish patients, respectively. Jewish patients had higher proportion stage II-IV pulmonary disease (78% vs. 51.2%) while their Arabic counterparts had higher proportion of stage I disease (70.8% vs. 41.7%). The proportion of extra-thoracic organ involvement was similar. Different disease phenotype indicated differed diagnostic procedures; higher proportion of mediastinoscopy for stage I disease among Arabic patients (47.9% vs. 20.8%, P = 0.015) and trans-bronchial biopsy for stage II-IV pulmonary disease among Jewish patients (25% vs. 8.35%, P = 0.05). Corticosteroids were used in a non-significantly higher proportion of Jewish patients (56.9% vs. 43.8%, P > 0.05). Of six sarcoidosis-related deaths (5%), five occurred in Jewish patients.

CONCLUSIONS:
This study has documented different forms of presentation, clinical manifestation, severity and prognosis of sarcoidosis present among patients of Arabic and Jewish origin residing in the area of northern Israel.

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Author information

Author/s: Yigla, Mordechai (M); Badarna-Abu-Ria, Nahal (N); Goralnik, Luda (L); Rubin, Ami-Hai E (AH); Weiler-Ravell, Daniel (D);

Affiliation: Division of Pulmonary Medicine, Rambam Medical Center, Haifa 31096, Israel. m_yigla(-atsign-)rambam.health.gov.il

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Respirology (Carlton, Vic.) (Respirology), published in Australia. (Language: eng)

Reference: 2006-Sep; vol 11 (issue 5) : pp 586-91

Dates: Created 2006/08/18; Completed 2007/01/09;

PMID: 16916331, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Aged
Aged, 80 and over
Arabs - ethnology
Child
Female

Humans
Israel - epidemiology
Jews - ethnology
Male
Middle Aged
Retrospective Studies
Sarcoidosis - epidemiology; ethnology

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