Nelarabine: efficacy in the treatment of clinical malignancies.

Full Abstract

Nelarabine is a nucleoside analog prodrug of 9-beta-D-arabinofuranosylguanine. Nelarabine is indicated for the treatment of adult and pediatric patients with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma whose disease has not responded to, or has relapsed after treatment with, at least two chemotherapy regimens. Nelarabine was granted Orphan Medical Product Status in Europe in June 2005, and accelerated approval by the US FDA in October 2005. The most common adverse events associated with nelarabine are neurotoxic in nature and have been dose-limiting.

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Author information

Author/s: Roecker, Andrew M (AM); Allison, Jeffery C (JC); Kisor, David F (DF);

Affiliation: Ohio Northern University College of Pharmacy, 525 South Main Street, Department of Pharmacy Practice, Ada, OH 45810, USA. a-roecker(-atsign-)onu.edu

Journal and publication information

Publication Type: Journal Article; Review

Journal: Future oncology (London, England) (Future Oncol), published in England. (Language: eng)

Reference: 2006-Aug; vol 2 (issue 4) : pp 441-8

Dates: Created 2006/08/22; Completed 2006/11/03; Revised 2007/11/15;

PMID: 16922610, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Arabinonucleosides - adverse effects; pharmacokinetics; pharmacology; therapeutic use
Child
Clinical Trials as Topic

Clinical Trials as Topic
Humans
Leukemia-Lymphoma, Adult T-Cell - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy

Associated Chemicals: Arabinonucleosides (0) ; nelarabine (0)

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