Applications of fMRI in translational medicine and clinical practice.

Full Abstract

Functional MRI (fMRI) has had a major impact in cognitive neuroscience. fMRI now has a small but growing role in clinical neuroimaging, with initial applications to neurosurgical planning. Current clinical research has emphasized novel concepts for clinicians, such as the role of plasticity in recovery and the maintenance of brain functions in a broad range of diseases. There is a wider potential for clinical fMRI in applications ranging from presymptomatic diagnosis, through drug development and individualization of therapies, to understanding functional brain disorders. Realization of this potential will require changes in the way clinical neuroimaging services are planned and delivered.

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Author information

Author/s: Matthews, Paul M (PM); Honey, Garry D (GD); Bullmore, Edward T (ET);

Affiliation: Centre for Functional Magnetic Resonance Imaging of the Brain, Dept. of Clinical Neurology, University of Oxford, UK. paul.m.matthews(-atsign-)gsk.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Nature reviews. Neuroscience (Nat Rev Neurosci), published in England. (Language: eng)

Reference: 2006-Sep; vol 7 (issue 9) : pp 732-44

Dates: Created 2006/08/22; Completed 2006/10/27; Revised 2006/11/15;

PMID: 16924262, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Brain - blood supply; metabolism; physiopathology
Brain Diseases - diagnosis; physiopathology; therapy
Cerebrovascular Circulation - physiology
Electroencephalography - methods; trends
Humans

Humans
Magnetic Resonance Imaging - methods; trends
Neuronavigation - instrumentation; methods; trends
Neuropharmacology - instrumentation; methods; trends
Preoperative Care - instrumentation; methods; trends
Recovery of Function - physiology

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