Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection.

Full Abstract

This study sought to investigate the efficacy of dextromethorphan (DM), diphenhydramine (DPH), and placebo (PL) for symptoms attributed to upper respiratory infections as determined by children, and to evaluate the concordance of perception of nocturnal symptoms between children and parents. A total of 37 children age 6 to 18 years of age were randomized in a double-masked fashion to receive a single bedtime dose of DM, DPH, or PL. Children found no significant difference in the effect of DM, DPH, or PL for any study outcome, and responses by parents and children were significantly correlated.

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Author information

Author/s: Yoder, Katharine E (KE); Shaffer, Michele L (ML); La Tournous, Susan J (SJ); Paul, Ian M (IM);

Affiliation: Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Grants: C06 RR016499 (Agency:NCRR NIH HHS) ; M01 RR010732 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Clinical pediatrics (Clin Pediatr (Phila)), published in United States. (Language: eng)

Reference: 2006-Sep; vol 45 (issue 7) : pp 633-40

Dates: Created 2006/08/24; Completed 2007/02/02; Revised 2007/12/03;

PMID: 16928841, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Antitussive Agents - therapeutic use
Child
Cough - drug therapy; etiology
Dextromethorphan - therapeutic use
Diphenhydramine - therapeutic use

Female
Humans
Male
Placebos
Respiratory Tract Infections - complications
Treatment Outcome

Associated Chemicals: Antitussive Agents (0) ; Placebos (0) ; Dextromethorphan (125-71-3) ; Diphenhydramine (58-73-1)

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