Research article summary (published 21 Aug 2006):

Serum antibodies to pneumococcal neuraminidase NanA in relation to pneumococcal carriage and acute otitis media.

Full Abstract

Pneumococcal neuraminidase, NanA, is a pneumococcal vaccine candidate. Prior culture-confirmed pneumococcal contacts were shown to induce serum anti-NanA antibodies during the first 2 years of life. The antibody concentrations at neither 12 nor 18 months were significantly associated with the risk of subsequent pneumococcal carriage or acute otitis media.

Learn Faster Today      Improve your study skills

Author information

Author/s: Simell, Birgit (B); Jaakkola, Teija (T); Lahdenkari, Mika (M); Briles, David (D); Hollingshead, Susan (S); Kilpi, Terhi M (TM); Käyhty, Helena (H);

Affiliation: Vaccine Immunology Laboratory, National Public Health Institute, Mannerheimintie 166, 0300 Helsinki, Finland. birgit.simell(-atsign-)ktl.fi

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol), published in United States. (Language: eng)

Reference: 2006-Oct; vol 13 (issue 10) : pp 1177-9

Dates: Created 2006/10/09; Completed 2007/01/08; Revised 2008/11/20;

PMID: 16928889, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acute Disease Adult Carrier State - blood; immunology; transmission Child, Preschool Humans Immunoglobulin G - blood

Immunoglobulin G - blood Infant Neuraminidase - immunology Otitis Media - blood; immunology Pneumococcal Infections - blood; immunology; transmission Streptococcus pneumoniae - enzymology; immunology

Associated Chemicals: Immunoglobulin G (0) ; Neuraminidase (EC 3.2.1.18)

Related articles

These are the highest related articles currently in the database:

• Acute otitis media in the era of effective pneumococcal conjugate vaccine: will new pathogens emerge? 6 Dec 2000
• Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media. 27 Feb 2006
• Development of antibodies to PspA families 1 and 2 in children after exposure to Streptococcus pneumoniae. 25 Aug 2008
• Immune response to surface protein A of Streptococcus pneumoniae and to high-molecular-weight outer membrane protein A of Moraxella catarrhalis in children with acute otitis media. 13 May 2000
• Pneumococcal serology in children's respiratory infections. 16 Dec 2007
• Comparison of serum antibodies to pneumolysin with those to pneumococcal capsular polysaccharides in children with acute otitis media. 30 Jan 1996
• Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media. 3 Sep 2000
• Pathogenesis of pneumococcal inflammation: otitis media. 6 Dec 2000
• The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae. 6 Dec 2000
• Pneumococcal serotypes from acute otitis media in rural Kentucky. 30 Aug 2002

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.