fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection.

Full Abstract

If fatigue in multiple sclerosis (MS) is related to an abnormal activation of the sensorimotor brain network, the activity of such a network should vary with varying fatigue. We studied 22 patients treated with interferon beta 1a (IFNbeta-1a; Avonex, Biogen, Cambridge, MA) with no fatigue (10) and with reversible fatigue (12). fMRI examinations were performed:
1) the same day of IFNbeta-1a injection (no fatigue; entry), 2) the day after IFNbeta-1a injection (fatigue; time 1), and 3) 4 days after IFNbeta-1a injection (no fatigue; time 2). Patients performed a simple motor task with the right, clinically unaffected hand. At time 1, compared with entry and time 2, MS patients with reversible fatigue showed an increased activation of the thalamus bilaterally. In MS patients without fatigue thalamus was more activated at entry than at time 1. In both groups at entry the primary SMC and the SMA were more activated than at times 1 and 2. At entry and time 1, when compared to patients with reversible fatigue, those without showed increased activations of the SII. Conversely, patients with reversible fatigue had increased activations of the thalamus and of several regions of the frontal lobes. An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNbeta-1a-induced fatigue in MS patients.

Learn Faster Today Improve your study skills

Author information

Author/s: Rocca, Maria A (MA); Agosta, Federica (F); Colombo, Bruno (B); Mezzapesa, Domenico M (DM); Falini, Andrea (A); Comi, Giancarlo (G); Filippi, Massimo (M);

Affiliation: Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

Journal: Human brain mapping (Hum Brain Mapp), published in United States. (Language: eng)

Reference: 2007-May; vol 28 (issue 5) : pp 373-82

Dates: Created 2007/04/25; Completed 2007/07/06;

PMID: 16933299, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adjuvants, Immunologic - adverse effects
Adult
Brain Mapping
Cerebral Cortex - blood supply; drug effects
Fatigue - chemically induced
Female
Humans
Image Processing, Computer-Assisted - methods

Interferon-beta - adverse effects
Magnetic Resonance Imaging
Male
Multiple Sclerosis, Relapsing-Remitting - drug therapy; physiopathology
Neuropsychological Tests
Oxygen - blood
Psychomotor Performance - drug effects
Time Factors

Associated Chemicals: Adjuvants, Immunologic (0) ; interferon beta 1a (145258-61-3) ; Interferon-beta (77238-31-4) ; Oxygen (7782-44-7)

These are the highest related articles currently in the database:

See 100+ related articles.