Steroidal saponins from Solanum nigrum.

Full Abstract

Six new steroidal saponins, solanigrosides C-H (2-7), and one known saponin, degalactotigonin (1), were isolated from the whole plant of Solanum nigrum. Their chemical structures were elucidated using spectroscopic analysis, chemical degradation, and derivatization. All seven compounds were tested for their cytotoxicity using four human tumor cell lines (HepG2, NCI-H460, MCF-7, SF-268). Only compound 1 was cytotoxic, with IC50 values of 0.25-4.49 microM.

Author information

Author/s: Zhou, Xinlan (X); He, Xiangjiu (X); Wang, Guanghui (G); Gao, Hao (H); Zhou, Guangxiong (G); Ye, Wencai (W); Yao, Xinsheng (X);

Affiliation: Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.

Journal and publication information

Publication Type: Journal Article

Journal: Journal of natural products (J Nat Prod), published in United States. (Language: eng)

Reference: 2006-Aug; vol 69 (issue 8) : pp 1158-63

Dates: Created 2006/08/28; Completed 2006/09/28;

PMID: 16933867, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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