Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys.

Full Abstract

Delta agonists such as SNC80 ((+)-4-[(aR)-a-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide) produce some cocaine-like behavioral effects and warrant evaluation as candidate "agonist" medications for cocaine abuse. The present study examined acute and chronic effects of the systemically active delta agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys. Acute SNC80 (0.32-3.2 mg/kg, i.m.) pretreatment dose-dependently decreased cocaine self-administration (0.0032 mg/kg/injection), but doses of SNC80 that decreased cocaine self-administration also decreased food-maintained responding. In chronic studies, SNC80 (0.32-3.2 mg/kg/h, i.v.) was delivered for 7 days, and food or cocaine (0.01 mg/kg/injection) was available during 4 daily components of food availability and 4 daily components of drug availability. Chronic SNC80 (1.8 mg/kg/h) tended to decrease cocaine self-administration but produced greater reductions in food-maintained responding. A higher dose of 3.2 mg/kg/h SNC80 eliminated both cocaine- and food-maintained responding and produced profound sedation in one monkey and was not tested in other monkeys. These findings indicate that SNC80 produced dose-dependent and non-selective reductions in cocaine self-administration. These results suggest that SNC80 is unlikely to be useful as a treatment for cocaine dependence.

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Author information

Author/s: Do Carmo, Gail Pereira (GP); Mello, Nancy K (NK); Rice, Kenner C (KC); Folk, John E (JE); Negus, S Stevens (SS);

Affiliation: Alcohol and Drug Abuse Research Center, McLean Hospital - Harvard Medical School, Belmont, MA 02478, USA.

Grants: K05-DA 00101 (Agency:NIDA NIH HHS) ; R01 DA011460-06 (Agency:NIDA NIH HHS) ; R01-DA 11460 (Agency:NIDA NIH HHS) ; R01-DA02519 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

Journal: European journal of pharmacology (Eur J Pharmacol), published in Netherlands. (Language: eng)

Reference: 2006-Oct; vol 547 (issue 1-3) : pp 92-100

Dates: Created 2006/09/19; Completed 2006/12/15; Revised 2008/11/20;

PMID: 16934797, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
Animals
Behavior, Animal - drug effects
Benzamides - pharmacology
Cocaine - administration & dosage
Cocaine-Related Disorders - physiopathology; prevention & control; psychology
Conditioning, Operant - drug effects
Dose-Response Relationship, Drug
Female

Female
Food
Macaca mulatta
Male
Piperazines - pharmacology
Receptors, Opioid, delta - agonists
Reinforcement Schedule
Self Administration
Time Factors

Associated Chemicals: Benzamides (0) ; Piperazines (0) ; Receptors, Opioid, delta (0) ; 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide (156727-74-1) ; Cocaine (50-36-2)

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