NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo.

Full Abstract

Behavioral stress facilitates long-term depression but impairs long-term potentiation in the hippocampus. Recent evidence in vitro demonstrates that the NR2B-containing N-methyl-D-aspartate subtype glutamate receptor antagonist Ro25-6981 prevents the behavioral stress-facilitated hippocampal long-term depression. It is, however, unknown whether Ro25-6981 influences hippocampal long-term depression and long-term potentiation induction in vivo under stressful condition. Here, we found that infusion of Ro25-6981 (2.3 microg in 6 microl, intracerebroventricular for 10 min) 30 min before low-frequency stimulation prevented the facilitation of hippocampal long-term depression by acute stress in anesthetized adult rats. Moreover, infusion of Ro25-6981 30 min before high-frequency stimulation reversed stress-impaired hippocampal long-term potentiation. These results suggest that the NR2B-containing N-methyl-D-aspartate subtype glutamate receptors are crucial for the effects of behavioral stress on hippocampal long-term depression and long-term potentiation in vivo.

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Author information

Author/s: Wang, Meina (M); Yang, Ya (Y); Dong, Zhifang (Z); Cao, Jun (J); Xu, Lin (L);

Affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, and the 2nd Xiangya Hospital of Central South University, Changsha, Hunan, PR China.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuroreport (Neuroreport), published in England. (Language: eng)

Reference: 2006-Aug; vol 17 (issue 12) : pp 1343-6

Dates: Created 2006/09/04; Completed 2006/10/18; Revised 2008/11/21;

PMID: 16951582, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Dose-Response Relationship, Radiation
Electric Stimulation - methods
Electroshock - adverse effects
Hippocampus - drug effects; physiopathology; radiation effects
Long-Term Potentiation - drug effects; physiology
Long-Term Synaptic Depression - drug effects; physiology

Male
Phenols - pharmacology
Piperidines - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; physiology
Stress, Physiological - etiology; pathology; physiopathology

Associated Chemicals: NR2B NMDA receptor (0) ; Phenols (0) ; Piperidines (0) ; Receptors, N-Methyl-D-Aspartate (0) ; Ro 25-6981 (0)

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