Research article summary (published 30 Aug 2006):

MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia.

Full Abstract

MLL/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.

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Author information

Author/s: Panagopoulos, Ioannis (I); Lilljebjörn, Henrik (H); Strömbeck, Bodil (B); Hjorth, Lars (L); Olofsson, Tor (T); Johansson, Bertil (B);

Journal and publication information

Publication Type: Case Reports; Letter; Research Support, Non-U.S. Gov't

Journal: Haematologica (Haematologica), published in Italy. (Language: eng)

Reference: 2006-Sep; vol 91 (issue 9) : pp 1287-8

Dates: Created 2006/09/07; Completed 2006/10/24; Revised 2007/11/15;

PMID: 16956839, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 17 Female Humans Infant

Myeloid-Lymphoid Leukemia Protein - genetics Nerve Tissue Proteins - genetics Oncogene Proteins, Fusion - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Translocation, Genetic

Associated Chemicals: GAS7 protein, human (0) ; MLL-GAS7 fusion protein (0) ; Nerve Tissue Proteins (0) ; Oncogene Proteins, Fusion (0) ; Myeloid-Lymphoid Leukemia Protein (149025-06-9)

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