A functional magnetic resonance imaging investigation of short-term source and item memory for negative pictures.

Full Abstract

We investigated the hypothesis that arousal recruits attention to item information, thereby disrupting working memory processes that help bind items to context. Using functional magnetic resonance imaging, we compared brain activity when participants remembered negative or neutral picture-location conjunctions (source memory) versus pictures only. Behaviorally, negative trials showed disruption of short-term source, but not picture, memory; long-term picture recognition memory was better for negative than for neutral pictures. Activity in areas involved in working memory and feature integration (precentral gyrus and its intersect with superior temporal gyrus) was attenuated on negative compared with neutral source trials relative to picture-only trials. Visual processing areas (middle occipital and lingual gyri) showed greater activity for negative than for neutral trials, especially on picture-only trials.

Learn Faster Today Improve your study skills

Author information

Author/s: Mitchell, Karen J (KJ); Mather, Mara (M); Johnson, Marcia K (MK); Raye, Carol L (CL); Greene, Erich J (EJ);

Affiliation: Yale University, New Haven, Connecticut 06520-8205, USA. karen.mitchell(-atsign-)yale.edu

Grants: AG025340 (Agency:NIA NIH HHS) ; AG09253 (Agency:NIA NIH HHS) ; AG15793 (Agency:NIA NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

Journal: Neuroreport (Neuroreport), published in England. (Language: eng)

Reference: 2006-Oct; vol 17 (issue 14) : pp 1543-7

Dates: Created 2006/09/07; Completed 2006/12/12; Revised 2007/12/03;

PMID: 16957605, status: MEDLINE (last retrieval date: 12/26/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Brain - blood supply; physiology
Brain Mapping
Emotions - physiology
Female
Humans

Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging
Male
Memory - classification; physiology
Oxygen - blood
Pattern Recognition, Visual - physiology
Photic Stimulation - methods

Associated Chemicals: Oxygen (7782-44-7)

These are the highest related articles currently in the database:

See 100+ related articles.