Memory-based detection of rare sound feature combinations in anesthetized rats.

Full Abstract

It is unclear whether the ability of the brain to discriminate rare from frequently repeated combinations of sound features is limited to the normal sleep/wake cycle. We recorded epidural auditory event-related potentials in urethane-anesthetized rats presented with rare tones ('deviants') interspersed with frequently repeated ones ('standards'). Deviants differed from standards either in frequency alone or in frequency combined with intensity. In both cases, deviants elicited event-related potentials exceeding in amplitude event-related potentials to standards between 76 and 108 ms from the stimulus onset, suggesting the independence of the underlying integrative and memory-based change detection mechanisms of the brain from the normal sleep/wake cycle. The relations of these event-related potentials to mismatch negativity and N1 in humans are addressed.

Author information

Author/s: Astikainen, Piia (P); Ruusuvirta, Timo (T); Wikgren, Jan (J); Penttonen, Markku (M);

Affiliation: Department of Psychology, University of Jyvaäskylaä, Jyvaäskylaä, Finland. piia.astikainen(-atsign-)psyka.iyu.fi

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuroreport (Neuroreport), published in England. (Language: eng)

Reference: 2006-Oct; vol 17 (issue 14) : pp 1561-4

Dates: Created 2006/09/07; Completed 2006/12/12;

PMID: 16957608, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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