High-performance liquid chromatography analysis of rubber allergens in protective gloves used in health care.

Full Abstract

A high-performance liquid chromatography (HPLC) method developed for analysis of zinc dithiocarbamates was validated and used to perform a survey of disposable medical gloves used in southern Sweden. The gloves were extracted with acetone at room temperature for 10 min by shaking. The extracts were injected into a polyether ether ketone lined HPLC column, and peaks were analysed by a diode-array detector. The survey shows that of 19 gloves analysed, 10 contained zinc diethyldithiocarbamate (0.070-3.5 mg/g), 3 contained zinc pentamethylenedithiocarbamate (1.0-4.3 mg/g), 4 contained zinc dibutyldithiocarbamate (0.9-1.1 mg/g), and 2 contained 2-mercaptobenzothiazole (0.005-0.008 mg/g). None of them contained thiurams.

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Author information

Author/s: Bergendorff, Ola (O); Persson, C (C); Hansson, C (C);

Affiliation: Department of Dermatology, Lund University, University Hospital, SE-221 85 Lund, Sweden. ola.bergendorff(-atsign-)skane.se

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies

Journal: Contact dermatitis (Contact Dermatitis), published in Denmark. (Language: eng)

Reference: 2006-Oct; vol 55 (issue 4) : pp 210-5

Dates: Created 2006/09/08; Completed 2006/12/28;

PMID: 16958918, status: MEDLINE (last retrieval date: 12/26/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Allergens - chemistry
Chromatography, High Pressure Liquid - methods
Dermatitis, Occupational - prevention & control
Gloves, Protective
Hand Dermatoses - prevention & control
Health Personnel

Health Personnel
Humans
Latex Hypersensitivity - prevention & control
Predictive Value of Tests
Rubber - chemistry
Thiocarbamates - chemistry

Associated Chemicals: Allergens (0) ; Thiocarbamates (0) ; zinc dibutyldithiocarbamate (136-23-2) ; Rubber (9006-04-6)

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